摘要
目的:探讨了超敏C反应蛋白(hs-CRP)、颗粒膜蛋白-140(GMP-140)和肌钙蛋白T(cTnI)水平的变化与冠心病(CHD)患者的关系及临床价值。方法:应用放射免疫分析、酶联法和免疫比浊法对91例CHD患者进行了血清hs-CRP、GMP-140和cTnI测定,其中稳定型心绞痛(SAP)42例,不稳定型心绞痛(UAP)34例,急性心梗死(AMI)15例,并与35名正常人作比较。结果:CHD患者血清hs-CRP、GMP-140和cTnI水平均非常显著地高于正常人组(P<0.01),急性AMI组和UAP组均高于SAP组(P<0.05),且血清hs-CRP水平与GMP-140、cTnI水平呈正相关(r=0.6214、0.6023,P<0.01)。结论:检测CHD患者血清hs-CRP、GMP-140和cTnI水平的变化及CHD的发生和发展以及疗效和预后观察具有重要的临床意义。
Objective To explore the clinical significance of changes of serum hs-CRP,GMP-140 and cTnI levels in patients with coronary heart diseases.Methods Serum GMP-140 （with RIA） ,cTnI （with ELISA） and hs-CRP （with immunoturbidity method） levels were determined in 91 patients with coronary heart diseases （42 SAP,34UAP,15AMI） and 35 controls.Results Serum hs-CRP,GMP-140,cTnI levels in patients with coronary heart diseases were significantly higher than those in controls （P〈 0.01） .Among the patients with of coronary heart diseases,the magnitude of changes of the levels of serum hs-CRP,GMP-140 and cTnI levels in AMI and UAP groups were significantly larger than those in SAP group （P〈 0.05） .Serum hs-CRP levels were positively correlated with serum GMP-140 and cTnI levels （r = 0.6214,0.6023,P〈 0.01） .Conclusion Serum hs-CRP,GMP140 and cTnI levels were closely related to the diseases process of coronary heart diseases and were of great clinical importance for assessment of the disease and outcome prediction.
出处
《放射免疫学杂志》
CAS
2010年第5期498-499,共2页
Journal of Radioimmanology
关键词
冠心病
超敏C反应蛋白
颗粒膜蛋白-140
肌钙蛋白T
稳定型心绞痛
不稳定型心绞痛
急性心肌梗死
coronary heart diseases （CHD）
high-sensitive C-reactive protein （hs-CRP）
granular membranous protein-140 （GMP-140）
troponin I （cTnI）
stable angina pectoris （SAP）
unstable angina pectoris （UAP）
acute myocardial infarction （AMI）
