白癜风患者治疗前后血清IL-2、IL-4和IFN-γ检测的临床意义

Clinical Significance of Measurement of Changes of Serum IL-2,IL-4 and IFN-γ Levels After Treatment in Patients with Vitiligo

目的:探讨白癜风患者治疗前后血清IL-2、IL-4和IFN-γ水平的变化及意义。方法:应用放免法和酶免法对37例白癜风患者进行了治疗前后血清IL-2、IL-4和IFN-γ的检测,并与35名正常人组作比较。结果:白癜风患者在治疗前血清IL-2水平非常显著地低于正常人组(P<0.01),而IL-4、IFN-γ水平则显著地高于正常人组(P<0.01),经治疗6个月后,与正常人组比较仍有显著性差异(P<0.05)。结论:白癜风患者存在自身免疫调节的异常。

Objective To explore the changes of serum IL-2,IL-4 and IFN-γ levels after treatment in patients with vitiligo.Methods Serum IL-2（with RIA）IL-4,IFN-γ（with ELISA）levels were examined in 37 patients with vitiligo both before and after treatment as well as in 35 controls.Results Before treatment,serum IL-2 levels in the patients were significantly lower than those in controls（P 0.01）,while the serum IL-4,IFN-γ levels were significantly higher（P 0.01）.After treatment for 6 months,the values were greatly corrected,but remained significantly different from those in controls（P 0.05）.Conclusion Vitiligo is a kind of auto-immune diseases with abmormal immuno-regulation.