吴茱萸次碱的合成、结构表征及体内抗肿瘤作用研究

Synthesis,Structure Characterization of Rutaecarpine and Its Antitumor Activity in vivo

以色胺和靛红酸酐为起始原料经三步反应合成吴茱萸次碱,通过元素分析I、R、质谱1、HNMR等对合成的目标化合物进行了表征,并考察了吴茱萸次碱对小鼠移植性肉瘤S180和肝癌H22的影响。结果表明,吴茱萸次碱高、中、低剂量组(20 mg.kg-11、0 mg.kg-1和5 mg.kg-1)对S180和H22的生长均具有抑制作用;且和环磷酰胺相比,对脾脏和胸腺损伤更小,甚至具有保护作用。

Rutaecarpine was obtained successfully with tryptamine and isatoic anhydride as raw material through three-step reaction.And the aim compound was characterized by elemental analysis,IR,MS,and 1HNMR.And the antitumor activity in vivo of rutaecarpine for S180 and H22 in mice were studied.The results showed that rutaecarpine of high,medium and low dose（20 mg·kg-1,10 mg·kg-1 and 5 mg·kg-1） could inhibit the growth of both S180 and H22 significantly.And comparing with the cyclophosphamide,the rutaecarpine did little damage to spleen and thymus,even had protection effect.