肠康舒组方药效初步研究

Preliminary pharmacodynamic of components of Changkangshu

目的:筛选出以中药有效组分配伍的肠康舒处方。方法:利用三硝基苯磺酸乙醇溶液复制溃疡性结肠炎大鼠模型,选择黄芪和黄连3个重量比例(1:1,1:3和3:1)。灌肠观察对大鼠肠重系数、炎症程度、溃疡面积、病变深度和纤维化的影响。结果:当确定肠康舒药味组成为:黄芪、黄连各6g;疗效最佳;饮片配伍与有效组分黄芪皂苷、黄芪多糖、黄连总碱配伍的疗效无明显差异。结论:实验证实肠康舒的有效组分能代替饮片配伍。

AIM：To sift out the effective ingredients ration from Changkangshu formula（Radix Astragali and Rhizoma Coptidis） in the treatment of ulcerative colitis（UC）.METHODS：The UC model rats were induced by trinitrobenzen sulfonic acid plus absolute ethanol（1：1）,Changkangshu decoction as enema was administered to rats to observe the influence on the enteric weight coefficient,inflammatory lesion.Ulcerative area and fibrogenesis.RESULTS：Prescription consisted of Radix astragali and Rhizoma coptidis（each 6 g） showed the strong curative effect.The combination of effective constituents,including astragaloside,astragalus polysaccharide and berberine,was the same the therapeutic effect as the decoction.CONCLUSION：The experiment suggested that the effective constitutents of Changkangshu formula should supply the place of prepared drugs in pieces.