长托宁联合突击量氯磷定治疗急性重度有机磷农药中毒疗效观察

Penehyclidine hydrochloride and pyradoxime methychloride in assault quantity in the treatment of acute severe organophosphorus pesticide poisoning

目的观察长托宁联合突击量氯磷定治疗急性重度有机磷中毒的作用。方法将72例口服急性急性重度有机磷中毒(AOPP)患者随机分为A、B、C三组,A组给予长托宁联合突击量氯磷定治疗,B组给予阿托品联合突击量氯磷定组治疗,C组给予阿托品联合常规量氯磷定治疗,观察其疗效。结果 A组与其他两组比较,患者意识清醒时间、机械通气时间、乙酰胆碱脂酶(CHE)恢复时间、住院时间均缩短,中间综合征发生率、患者死亡率降低,治愈率提高,差异均具有显著统计学意义(P<0.01)。结论长托宁联合突击量氯磷定是治疗急性重度有机磷中毒非常有效的方法。

Objective To observe the efficacy of penehyclidine hydrochloride and pyradoxime methychloride in assault quantity in the treatment of severe acute organophosphorus pesticide poisoning（SAOPP）.Methods 72 cases with oral SAOPP were randomly divided into group A,B and C.Patients in group A were treated with penehyclidine hydrochloride and pyradoxime methychloride in assault quantity,patients in group B with atropine and pyradoxime methychloride in assault quantity,and patients in group C with atropine and pyradoxime methychloride in regular quantity.The variations of efficacy were measured and analyzed in three groups.Results Compared with patients in group B and C,group A had shorter time of conscious recovery,mechanical ventilation,average hospitalization duration and recovery time of cholinesterase,the incidence of intermediate syndrome and the mortality were lower,and the curing rate was higher.Conclusion Penehyclidine hydrochloride and pyradoxime methychloride in assault quantity is a very effective way to treat acute severe organophosphorus pesticide poisoning.