高容量血液滤过治疗严重颅脑损伤后多器官功能障碍的研究

High-volume Hemofiltration for Severe Traumatic Brain Injury Study of Multiple Organ Dysfunctions

探讨高容量血液滤过治疗严重颅脑损伤后多器官功能障碍患者的预后及与肿瘤坏死因子(TNF-α)、白介素-1、白介素-10水平的变化。无肝素化血液滤过治疗重度颅脑损伤多脏器衰竭患者,监测病人14 d死亡率及监测病人、24 h、48 h TNF-α、IL-1、IL-10变化。结果血液滤过治疗24 h及48 h的TNF-α、IL-1、IL-10水平明显低于血滤治疗前。治疗14 d后治疗组死亡率明显低于对照组。高容量血液滤过治疗严重颅脑损伤后多器官功能障碍的患者,能够降低炎症介质改善其预后。

Objective High-volume hemofiltration for severe traumatic brain injury with multiple organ dysfunction and prognosis in patients with tumor necrosis factor（TNF-α）,interleukin-1,interleukin-10 level changes.Without heparin hemofiltration in patients with severe head injury with multiple organ failure,monitoring of patient mortality and monitoring hours for 14 days,24 hours,48 hours,TNF-α,IL-1,IL-10 changes.Results hemofiltration 24 hours and 48 hours of TNF-α,IL-1,IL-10 levels were significantly lower than the blood filtration treatment.Treatment 14 days after the treatment group mortality was significantly lower than the control group.Conclusion The treatment of high-volume hemofiltration after severe brain injury patients with multiple organ dysfunctions can reduce the inflammatory mediators to improve their prognosis.