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动静脉内瘘血栓形成与可溶性内皮细胞蛋白C受体的关系 被引量:3

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摘要 自体动静脉内瘘(AVF)是慢性肾衰竭(CRF)维持性血液透析(MHD)患者较理想的血管通路.内瘘丧失功能仍然困扰着医生和患者,其最常见原因为血栓形成,因此,了解内瘘血栓形成的原因、影响因素,预测血栓形成以便早期干预成为人们关注的问题.本研究通过检测已行AVF成形术患者的血浆可溶性内皮细胞蛋白C受体(soluble endothelial cell protein C receptor,sEPCR)水平,探讨其在AVF血栓形成患者中的预测价值及其变化的可能原因.
出处 《中华肾脏病杂志》 CAS CSCD 北大核心 2010年第9期714-715,共2页 Chinese Journal of Nephrology
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参考文献6

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二级参考文献27

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共引文献39

同被引文献19

  • 1李立,王笑云,刘殿阁,刘必成,高民.维持性血液透析患者微炎症状态与血管通路失功的相关研究[J].中国血液净化,2007,6(10):538-542. 被引量:40
  • 2Misra S, Shergill U, Yang B, et al. Increased expression of HIFt lalpha,VEGF-A and its receptors,MMP-2 ,TIMP-1 and ADAMTS-1] at the venous stenosis of arteriovenous fistula in a mouse model wit renal insufficiency. J Vasc Interv Radiol, 2010, 21 ( 8 ) : 1255-1261 .].
  • 3Ridker P M, Howard C P, Walter V, et al. Effects of interleukin-1 inhibition with canakinumab on hemoglobin A1 c, lipids, C-reactive protein, interleukin-6 and fibrinogen: a phase IIb randomized placebo controlled trial. Circulation, 2012, 126 (23) : 2739-2748.
  • 4Chou C Y, Kuo H L, Yung Y F, et al. C-reactive protein predicts vascular access thrombosis in hemodialysis patients. Blood Purif, 2006, 24(4) : 342-346.
  • 5Saposnik B, Reny J L, Gaussem P,et al. A haplotype of the EPCR gene is associated with increased plasmal evels of sEPCR and is a candidate risk factor for thrombosis. Blood, 2004, 103: 1311-1318.
  • 6Mosnier L O, Griffin J H. Protein C anticoagulant activity in relation to anti-inflammatory and anti-apoptotie activities. Front Biosei, 2006, 11 : 2381-2399.
  • 7Simioni P, Morboeuf O, Toguin G, et al. Soluble endothelial protein C receptor(sEPCR) levels and venous thromboembolism in carriers of two dysfunctional protein C variants. Thrombosis Research, 2006, 117(5) : 523-528.
  • 8潘秀贤,蔡焕荣,李兵.创伤性四肢骨折患者血液流变学及凝血指标的改变及其临床意义[J].海南医学,2010,21(9):104-105. 被引量:22
  • 9张子彦,张敏,柳惠荣.2型糖尿病患者血浆可溶性内皮细胞蛋白C受体和凝血酶激活的纤溶抑制物的变化及意义[J].苏州大学学报(医学版),2010,30(1):178-179. 被引量:9
  • 10于敏,王姣,史耀勋,刘容锐,刘晓玲,熊锡山,文娜,崔冬妮.慢性肾衰竭微炎症状态发生机制的研究进展[J].中华医院感染学杂志,2010,20(10):1498-1500. 被引量:35

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