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减少GnRHa剂量对长方案促排卵卵巢反应性的影响 被引量：4

Effects of Reducing Dose of GnRHa on Ovarian Response with Long Protocol in Controlled Ovarian Hyperstimulation
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摘要 目的:探讨减少GnRHa剂量对长方案促排卵的卵巢反应性影响。方法:对37例采用长方案进行促排卵且第一周期未妊娠或流产的患者进行自身对照研究,第一个周期GnRHa用量为0.05mg/d,第二个周期GnRHa用量为0.03mg/d。结果:Gn使用天数、Gn用量、受精率第一、第二促排卵周期间无显著性差异(P>0.05)。获卵数、可移植胚胎数第二周期组较第一周期组显著增加(P<0.05)。结论:本研究认为在长方案促排卵过程中减少GnRHa的剂量可以增加获卵数,改善卵巢反应性,增加IVF妊娠率。 Objective：To study the effects of reducing dose of GnRHa on ovarian response with long protocol in controlled ovarian hyperstimulation（COH）.Methods：A self controlled analysis was performed on a total of 37 IVF patients who were treated with long protocol in COH.The first cycle GnRHa dose was 0.05 mg/d and IVF outcomes were failure or abortion.The second cycle GnRHa dose was 0.03 mg/d.Results：No significant differences were observed in stimulation days,gonadotrophin ampoules and fertilization rate.The number of oocyte retrieved,the number of embryo that could be transferred of the second cycle were higher than those of the first cycle.Conclusion：Reducing dose of GnRHa in long protocol of COH could increase the number of oocyte retrieved, improve ovarian response and IVF outcome.
作者 王慧焱 孙海翔 王玢 陈华
机构地区 南京大学医学院附属鼓楼医院生殖医学中心
出处 《生殖与避孕》 CAS CSCD 北大核心 2010年第9期638-640,共3页 Reproduction and Contraception
关键词 GNRHA 剂量 长方案 体外受精-胚胎移植(IVF-ET) GnRHa dose long protocol IVF-ET
分类号 R714.8 [医药卫生—妇产科学]
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参考文献11

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同被引文献37

  • 1董方莉,谭丽,郑英.影响子宫内膜接受性的相关因素研究进展[J].国外医学（计划生育分册）,2005,24(6):305-308. 被引量：6
  • 2李艳萍,张琼,刘能辉,冷灵芝.来曲唑与克罗米酚对子宫内膜整合素α_Vβ_3和基质金属蛋白酶组织抑制因子-3表达的影响[J].生殖医学杂志,2006,15(6):376-379. 被引量：8
  • 3Keay SD,Liversedge NH,Mathur RS,et al.Assisted conception following poor ovarian response to gonadotropin stimulation[J].Br J Obstet Gynaecol,1997,104 (5):521-527.
  • 4Surrey ES.Management of the poor responder:the role of GnRH agonists and antagonists[J].Assist Reprod Genet,24(12):613-619.
  • 5Surrey ES,Schoolcraft W.B.Evaluating strategies for improving ovarian response of the poor responder undergoing assisted reproductive techniques[J].Fertil Steril,2000,73(4):667-676.
  • 6Schoolcraft WB,Surrey ES,Minjarez DA,et al.Management of poor responders:Can outcomes be improved with a novle gonadotropin-releasing hormone antagonist/letrozole protocol[J].Fertil and Steril,2008,89(1):151-156.
  • 7Demirol A,Gurgan T.Comparision of microdose flare-up and antagonist multiple-dose protocls for poor-responder patients:a randomized study[J].Fertil Steril,2009,92(2):481-485.
  • 8Davar R,Oskouian H,Ahmad S,et al.GnRH antagonist/letrozole versus microdose GnRH agonist flare protocol in poor responders undergoing in vitro fertilization[J].Taiwan J Obstet Gynecol,2010,49(3):297-301.
  • 9Karimzadeh MA,Mashayekhy M,Mohammadian F,et al.Comparision of mild and microdose GnRHa agonist flare protocls and IVF outcome in poor responders[J].Arch Gynecol Obstet,2011,283(5):1159-1164.
  • 10Melo M A,Garrido N,A.lvarez C,et al.Antral follicle count(AFC)can be used in the prediction of ovarian response but can not predict the oocyte/embryo quality or the in vitro fertilization outcome.in an egg donation program[J].Fertil Steril,2009,91(1):148-156.

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生殖与避孕
2010年 第9期

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