胰肾联合移植术后的生命质量评估

Evaluation of quality of life after simultaneous pancreas-kidney transplantation

目的拟探讨胰肾联合移植术后糖尿病并发肾功能衰竭患者生命质量的状况。方法回顾分析我院糖尿病并发肾功能衰竭患者的基本资料,同时用健康测量量表SF-36针对糖尿病伴发肾功能衰竭患者术前、术后2年、术后4年进行评估。结果 8例糖尿病并发肾功能衰竭患者除1例出现脑血管意外家人放弃治疗外,其他所有患者均恢复顺利,接受了平均时间为23.3月(1～56月)的随访。术后血糖、C肽、肌酐稳定。术后2年评分与术前相比较,SF-36八个维度的评分均有显著性改善(P<0.05),且基本与中国正常人群评分相似(P>0.05)。结论胰肾联合移植术能明显改善糖尿病并发肾功能衰竭患者的生命质量。

Objective To evaluate the influence of simultaneous pancreas-kidney（SPK） transplantation on the quality of life of diabetic recipients with end-stage renal disease.Methods We performed a retrospective analysis of the data of diabetic patients with end-stage renal disease and evaluated the quality of life of the recipients using SF-36 health survey.Results One patient died of cerebrovascularaccident,and 7 patients recovered smoothly.During the follow-up lasting fora mean of 23.3 months,the blood glucose,C-peptide and creatine levels of the patients remained stable.The score of 8 domains of SF-36 of the diabetic recipient at 2 years after SPK transplantation showed a significant improvement compared with that before the operation,similar to that of Chinese normal population（P〉0.05）.Conclusions SPK transplantation can achieve a significant improvement of the quality of life of diabetic patients with end-stage renal disease.