甘露聚糖肽胶囊联合0.5%鬼臼毒素酊治疗尖锐湿疣的临床疗效观察

Clinical observation on mannatide capsule in combine with Podophyllotoxin Tincture for condyloma acuminatum

目的:进一步评价甘露聚糖肽联合鬼臼根树脂溶液治疗尖锐湿疣的有效性与安全性。方法:将126例入选病例,按照随机数字表随机分为治疗组63例,给予0.5%鬼臼毒素酊的同时加服甘露聚糖肽胶囊;对照组63例,仅给予0.5%鬼臼毒素酊;1周为一疗程,用药不超过5个疗程,疣体完全消退者继续随访至第18周以观察复发情况。结果:①痊愈率:观察组与对照组第1、2、3、4周的痊愈率分别为29.03%、26.22%,40.32%、32.78%,80.6%、62.3%,90.3%、73.78%,其中第3、4周两组比较具有统计学学差异(p<0.05);②复发率:观察组与对照组第6、12、18周的复发率分别为8.06%、6.55%,9.67%、29.5%,9.67%、37.7%其中第12、18周两组比较具有统计学差异(p<0.05);③不良反应:经随访观察,两组发生了红斑、水肿、糜烂、灼热、疼痛、瘙痒、溃疡、脱屑等不良反应,其中两组比较观察组红斑、水肿、糜烂、溃疡的发生率低于对照组,具有统计学差异(p<0.05)。结论:甘露聚糖肽联合0.5%鬼臼毒素酊治疗尖锐湿疣疗效好,复发率低,不良反应较少。

Objective：To further assess the efficacy and safety of combine therapy of mannatide capsule and Podophyllotoxin Tincture in the treatment of CA.Methods： 104 patients with CA were randomly divided into 2 groups according to random number table. The control group was given 0.5 % Podophyllotoxin Tincture and the observation group were treated with mannatide capsules on the basis of control group. Results： 1 ） cure rate： The cure rate of observation and control groups were 29. 03% ,26.22% ,40.32% ,32.78% ,80.6% ,62.3%, ,90.3% ,73.78% respectively on week 1,2,3,4, and it has difference on week 6,12,18 between the two（p 〈0. 05） ;2） relapse rate：The relapse rate of two groups were 8.06% ,6.55% ,9.67% ,29.5%, 12- 9% ,37.7% respectively,with difference between the two on week 12,18 ; 3） AD ： The two groups occurred erythema edema erosion scorching ache pruritus ulcer desquamation etc; and the incidence of erythema edema erosion ulcer in obser- vation group was smaller than the control group. Conclusions：Combine therapy of mannatide capsule and 0.5% Podophyllotoxin Tincture was safe and effective for the treatment of CA.