睡眠呼吸暂停伴高血压中原发性醛固酮增多症按血压分类的筛查分析

The study of screening rates of primary aldosteronism in obstructive sleep apnea syndrome with hypertension as the blood pressure classification

目的:描述阻塞性睡眠呼吸暂停低通气综合征(OSAS)合并高血压患者中,原发性醛固酮增多症(PA)按血压分类的筛查情况。方法:回顾性分析新疆自治区人民医院高血压诊疗中心337例确诊为OSAS合并高血压的患者,在标化状态下以坐位血浆醛固酮/肾素比值≥25为PA的筛查标准。结果:①OSAS合并单纯收缩期高血压中PA筛出4例,初筛率是21.05%;OSAS合并单纯舒张期高血压中PA筛出9例,初筛率是12.68%;OSAS合并二者均高的高血压中PA筛出29例,初筛率是16.48%。但不同亚组间PA初筛率无显著差异。②OSAS合并1级高血压中筛出18例PA,初筛率是15%;OSAS合并2级高血压中筛出18例PA,初筛率是18.75%;OSAS合并3级高血压中筛出6例PA,初筛率是12%。但不同级别间PA初筛率无显著差异。结论:在OSAS合并高血压患者中,按血压分类的PA初筛率没有不同。

Objective：To analyze the screening rates primary aldosteronism in obstructive sleep apnea syndrome with hypertension as the blood pressure classification.Method：Retrospective study was performed based on in-patients with hypertension and OSAS in Sleep monitoring center in department of hypertension.PA was screened by the ARR cut-off≥25（ng·L-1）/（μg·L-1·h-1）in the condition of washout of all interfering antihypertensive medications.Result：①There were 4（21.05%）PA in isolated systolic hypertension with OSAS;there were 9（12. 68%）PA in isolated diastolic hypertension with OSAS;there were 29（16.48%）PA in both systolic and diastolic hypertension with OSAS.②There were 18（15.00%）PA in first grade hypertension with OSAS;there were 18 （18.75%）PA in second grade hypertension with OSAS;there were 6（12%）PA in first third hypertension with OSAS.Conclusion：There are no significant differences about the screening rates of PA as the blood pressure classification in OSAS with hypertensio.