小剂量32P加平阳霉素治疗婴幼儿颌面部血管瘤的疗效

Efficacy of 32P and pinyangmycin injection in combination on maxillofacial hemangioma in infants and children

目的 探讨和评价小剂量32P和平阳霉素联合治疗婴幼儿颌面部血管瘤的疗效.方法 将399例患者随机分为3组.（1）32P胶体治疗组：100例,男37例,女63例.取32P 0.37～0.74 MBq/cm3,2%利多卡因0.5 ml,生理盐水适量,配成混合液行瘤体内多点注射,2周1次,2次为1个疗程.（2）平阳霉素治疗组：99例,男30例,女69例.取平阳霉素1 mg/cm3,2%利多卡因0.5 ml,生理盐水适量,配成混合液于瘤体内多点注射,方法同上.（3）32P胶体加平阳霉素治疗组：200例,男64例,女136例.取32P 0.25 MBq/cm3,平阳霉素0.5 mg/cm3,2%利多卡因0.5 ml,生理盐水适量,配成混合液于瘤体内多点注射,方法同上.结果 32P胶体加平阳霉素治疗组治愈率88.5%;32P胶体治疗组治愈率77.0%;平阳霉素治疗组治愈率71.7%.3种方法的有效率差异有统计学意义（P＜0.05）.结论 32P胶体、平阳霉素、32P加阳霉素治疗血管瘤均有疗效,但32P胶体加平阳霉素联合治疗血管瘤作用强,剂量小于单独使用,且方法简便易行,安全可靠,并发症少.

Objective To explore and evaluate the effect of 32P and pinyangmycin injected in combination for the treatment of maxillofacial hemangioma. Methods The patients were randomly divided into three groups. The first group of patients was treated with 32P; 100 patients were enrolled in this group, of which 37 were male and 63 female. 32P dosage between 0.37 and 0. 74 MBq per cm3 was prepared together with 0.5 ml of 2 %lidocaine, and appropriate normal saline, and then the mixture was injected into hemangioma every two weeks. The second group was given pinyangmycin, and the third group received both 32P and pinyangmycin. The second group included 30 male and 60 female, and the third group 64 male and 136 female. The dose and frequency were given as the same to the first group. Results 88.5 % of patients were cured using both 32P and pinyangmycin, and the cure rate was 77.0 % and 71.7 % with either 32P or pinyangmycin. Conclusion These results prove that 32P and pinyangmycin injected in combination for the treatment of maxillofacial hemangioma is more effective than either 32P or pinyangmycin alone, and furthermore, the method is easy, safe and has less complications.