PLGA组织工程支架材料在SBF中的降解性能和生物矿化性能

Degradation and Bio-mineralization Performances of PLGA Tissue Engineering Scaffolds in SBF

本文采用pH值测量、特性粘度、失重、DSC和电子探针的研究方法,研究了PLGA组织工程支架在模拟体液中的降解性能和生物矿化性能。研究发现随着在SBF中浸泡时间的增长,PLGA支架材料的分子量不断下降;浸泡在SBF中的PLGA组织工程支架材料的重量由沉积进程和降解进程共同决定;DSC测试显示,浸泡在SBF中的PLGA组织工程支架材料的羟基乙酸单元(GA)相对于乳酸单元(LA)更易降解;电子探针测试显示,浸泡在SBF中的PLGA组织工程支架材料表面有磷酸盐沉积物产生。

We studied the degradation and bio-mineralization performances of poly（lactic-co-glycolicacid）（PLGA） tissue engineering scaffolds in simulated body fluid（SBF） by measuring pH value of SBF,the weight loss rate of scaffolds,the molecular weight change of the materials and analyzing differential scanning calorimetry（DSC） curves and electron probe pictures of scaffolds.We found that the molecular weight of PLGA scaffold decreased with increasing time.The weight of the PLGA scaffold was affected by the degradation process and deposition process.The DSC curves of PLGA scaffolds showed that GA chains of PLGA degraded faster than LA chains of PLGA in SBF.The electron probe pictures of PLGA scaffolds showed that phosphate appeared on the surfaces of PLGA tissue engineering scaffolds.