基质金属蛋白酶2抑制物在鼻咽癌中的表达及与其生物学行为的关系

Expression of tissue inhibitor of metalloproteinase-2 in nasopharyngeal carcinoma

目的:研究基质金属蛋白酶2抑制物(TIMP2)在鼻咽癌中的表达及其与鼻咽癌生物学行为的关系。方法:采用免疫组织化学ElivisionPlus二步法对50例鼻咽癌组织、15例炎性鼻咽黏膜组织TIMP2进行检测,并进行χ2检验。结果:免疫组织化学结果显示TIMP2在鼻咽癌组织中表达显著高于炎性鼻咽黏膜组织(P<0.05)。TIMP2在有淋巴结转移者极显著高于无淋巴结转移者(P<0.01)。TIMP2随临床浸润分期升高其表达上调,但差异无统计学意义(P>0.05)。结论:表明TIMP2在鼻咽癌细胞突破基底膜向外扩散及转移中起着重要作用,MMP2/TIMP2比率失衡在判断鼻咽癌侵袭性、估计其预后中有一定意义。

Objective：To study the expression of tissue inhibitor of matrix metalloproteinase 2（TIMP2） in the nasopharyngeal carcinoma and to evaluate the relationships between the expression of TIMP2 and biological behavior of NPC.Method：The expression of TIMP2 was observed by immunohistochemical technique in 50 cases with nasopharyngeal carcinoma and 15 cases of Inflammation nasopharyngeal tissues.Result：The positive rates of TIMP2 are significantly higher in NPC than in Inflammation tissues（P0.05）.The expression of TIMP2 in-crease significantly with lymph node metastasis（P0.01）,but had no relevant to the rise clinical invasion stage （P0.05）.Conclusion：The results indicate that TIMP2 may play a critical role in assisting carcinoma cell to degrade basement membrane to invade surrounding tissues and to form metastatic colonies in lymph node.Especially the unbalance in MMP2/TIMP2 has probaly aprognostic value in nasopharyngeal carcinoma.