摘要
目的 研究雷公藤甲素洗脱支架抑制血管新生内膜增殖的有效性、对内皮功能的影响及支架安全性. 方法 将16只冠状动脉再狭窄模型小型猪完全随机分为2组,每组8只,分别植入雷公藤甲素洗脱支架和雷帕霉素支架,12周时比较2组形态测量学、组织病理学、血浆内皮素水平及生化检测结果. 结果 雷公藤甲素组的新生内膜面积[（0.74±0.05）mm^2]与雷帕霉素组[（0.70±0.04）mm^2]相似,但差异无统计学意义（P＞0.05）.雷公藤甲素组4周的内皮素血浆水平[（76.1±20.5）ng/L]低于雷帕霉素组[（88.3±17.9）ng/L],但差异无统计学意义（P＞0.05）.血生化检查未发现雷公藤甲素洗脱支架对受试动物产生毒副作用. 结论 雷公藤甲素洗脱支架在12周内能够抑制新生内膜增殖,对内皮有一定保护作用,有较好的安全性.
Objective To investigate the anti-proliferation and endothelial protecting effect of triptolide-eluting stent. Methods Experimental porcines were divided into 2 groups with 8 porcines in each group：triptolide-eluting stent group and rapamycine-eluting stent group.Morphometric,histopathologic,RIA and biochemical staining analysis were compared between the two groups 12 weeks after stenting in porcine model of coronary restenosis. Results The neointimal areas of triptolide-eluting stents（0.74±0.05）mm^2 were similar to rapamycine-eluting stents（0.70±0.04）mm^2（P 〉0.05）.At 4 weeks,plasma endothelin-1 was lower in triptolide group（76.1±20.5）ng/L than that in rapamycine group（88.3±17.9）ng/L.No evidence of toxic effects had been found in the experimental animals related to triptolide-eluting stent. Conclusions Triptolide-eluting stent may inhibit neointimal prolieration during 12 weeks.Triptolide probably takes part in protecting endothelial function.
出处
《中国医药》
2010年第11期973-975,共3页
China Medicine
基金
首都医学发展科研基金项目（03-11-09）
