摘要
目的:观察异丙嗪(promethazine,Prom)对小鼠利多卡因(lidocaine)致惊厥作用的影响。方法:腹腔注射利多卡因建立小鼠惊厥模型,观察腹腔注射3种剂量的异丙嗪对小鼠惊厥持续期、惊厥发生率和死亡率的影响。结果:异丙嗪可剂量依赖性地缩短小鼠利多卡因中毒惊厥的持续期(P<0.01),但对惊厥发生率、死亡率无显著影响(P>0.05)。结论:异丙嗪缩短利多卡因惊厥持续期,有一定的抗惊厥作用。
Objective： To observe the effect of promethazine on convulsion function of lidocaine in mice. Methods： We established a mouse model of convulsive by intraperitoneal injection of lidocain, then intraperitoneally injected 3 doses of promethazine respectively. We observed the effect of promethazine on convulsion duration, incidence of seizures and death rate of lidocaine in mice. Results： Promethazine can dose-dependently reduce the duration of lidocaine seizures （P〈0.01） in mice, but had no significant improvement in the incidence of seizures and mortality （P〉0.05）. Conclusion： Promethazine has a certain degree of anticonvulsant effect against lidocaine induced convulsions.
出处
《药学与临床研究》
2010年第5期438-439,共2页
Pharmaceutical and Clinical Research
基金
国家自然科学基金资助项目(39970715)
江苏省自然科学基金资助项目(BK200143)
