肝硬化合并胆囊结石多因素Logistic回归分析

Cirrhosis of the Liver Gallstones Multivariate Logistic Regression Analysis

目的:探讨肝硬化患者发生胆囊结石的相关影响因素。方法:回顾性分析我院肝病科244例确诊为肝硬化的住院病人,研究胆囊结石发生率,并探讨性别、酗酒史、Child-pugh分级、门静脉内径宽度(PVW)、血清白蛋白浓度(ALB)、血清总胆红素浓度(TBIL)、凝血酶原时间(PT)、胆囊壁厚度(GBW)、有无腹水等与胆囊结石发生率的关系并进行Logistic回归分析。结果:Logistic回归分析显示Child-Pugh分级、腹水是肝硬化并发胆囊结石的独立危险因素(OR=4.019,P=0.003:OR=4.062,P=0.041)。结论:临床治疗应积极控制低蛋白血症,防止高胆红素血症,控制腹水,可望降低和预防肝硬化胆囊结石的发生。

Objective：To Investigate Gallstones in patients with cirrhosis related factors.Methods：Retrospective analysis of 244 patients in our hospital Division liver cirrhosis patients diagnosed,the incidence of gallstones and to explore gender,history of heavy drinking,Child-pugh classification,portal vein width（PVW） ,serum albumin concentration（ALB） ,serum total bilirubin concentration（TBIL） ,prothrombin time（PT） ,gallbladder wall thickness（GBW） ,ascites and the relationship between the incidence of gallstones and conduct Logistic regression analysis.Results：Logistic regression analysis showed that Child-Pugh classification,liver cirrhosis complicated by ascites is an independent risk factor for gallstones（OR=4.019,P=0.003：OR=4.062,P=0.041） .Conclusion：Child-Pugh classification,liver cirrhosis complicated by ascites is an independent risk factor for gallbladder stones.Clinical treatment should be actively controlled hypoproteinemia,hyperbilirubinemia to prevent,control ascites,is expected to reduce the occurrence and prevention of liver cirrhosis gallstones.