9-羟基利培酮的体内过程

In vivo processes of 9-hydroxy-risperidone

9-羟基利培酮是非典型抗精神病药利培酮的主要活性代谢产物,其药理活性是母药的70%,比母药有更长的半衰期和更高的稳态血药浓度。帕潘利酮(利培酮缓释片)与利培酮片在整体疗效无明显差异,但是帕潘利酮能更有效地改善精神分裂症患者的社会功能,为此本文介绍了关于其体内过程(分布、代谢和排泄)的研究。

9 -hydroxy- risperidone （RIP） is the major active metabolite of risperidone , an atypical antidepressant. The pharmacological activity of 9 - OH - RIP is 70% of that of its parent drug and it has a longer half- life and a higher steady -state plasma concentration. Studies have shown that there is no significant difference between risperidone and pali- peridone in overall efficacy, but paliperidone can more effectively im- prove the social function of patients with schizophrenia. In this article, researches on drug＇s in vivo processes （distribution, metabolism and ex- cretion） are expounded in order to provide references for further research and rational application of the drug.