期刊文献+

不同剂量阿托伐他汀的降脂效果观察 被引量:1

下载PDF
导出
摘要 高脂血症是冠心病的危险因素之一,调整血脂能防止斑块破裂,减少冠心病致死率和致残率。阿托伐他汀属于3-羟基-3甲基戊二酰辅酶A(HMG-CoA)还原酶抑制剂,通过抑制HMG—CoA还原酶,减少肝细胞合成及储存胆固醇,加快低密度脂蛋白胆固醇(LDL-C)的代谢清除,从而降低血中总胆固醇(TC)、LDL-C水平,为治疗冠心病的基础用药。
出处 《实用医药杂志》 2010年第10期887-889,共3页 Practical Journal of Medicine & Pharmacy
  • 相关文献

参考文献6

二级参考文献21

  • 1Slamler J, Wentworth D, Neaton JD. Is relationship between serum cholesterol a nd risk of premature death from coronary heart disease continuous and graded ? F indings in 356,222 primary screenees of the Multiple Risk Factor Intervention Tr ial (MRFIT). JAMA, 1986,256:2823-2828.
  • 2Castelli WP, Garrison RJ,Wilson PwF, et al. Incidence of coronary heart disea se and lipoprotein cholesterol levels: the Framing ham Study. JAMA, 1986, 256:28 35-2838.
  • 3Randomized trial of cholesterol lowering in 4,444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study(4S).Lancet,1994,344:1383 -1389.
  • 4Frick MH, Elo O, Haapa K, et al. Helsinki Heart Study: primary- prevention t ri al with gemfibrozil in middle-aged men with dislipidemia. Safety of treatment ,c hages in risk factors, and incidence of coronary heart disease. N Engl J Med, 1 987,317:1237-1245.
  • 5Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease wit h pravastatin in men with hypercholesterolemia. West of Scotland Coronary Preven tion Study Group. N Engl J Med,1995,333:1301-1307.
  • 6Downs JR, Clearfield M, Weis S, et al. Primary prevention of acute coronary e v ents with lovastatin in men and women with average cholesterol levels: results o f AFCAPS/TexCAPS. Air Force/Texas Coronary Artherosclerosis Prevention Study. JAMA .1998;279:1615-1622.
  • 7Summary of the second report of the National Cholesterol Education Program (NC EP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholestero l in Adults ( Adult Treatment Panel II Report). JAMA, 1993, 269:3015-3023.
  • 8Report of the National Cholesterol Education Program Expert Panel on Detection , Evaluation, and Treatment of High Blood Cholesterol in Adults. The Expert Pan el. Arch Intern Med, 1998, 148:36-69.
  • 90 Pearson TA, Laurora I, Chu H, et al. The lipid treatment assessment project (L -TAP):a multicenter survey to evaluate the percentages of dyslipidemic patients receiving lipid-lowering therapy and achieving low-density lipoprotein choles terol goals. Arch Intern Med, 2000, 160:459-467.
  • 10Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 subjects with coronary heart disease: The Scandinavian Simvastatin Survival Study(4S). Lancet,1994,344:1383-1389.

共引文献505

同被引文献23

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部