氯胺酮依赖者脑功能活动的局部一致性改变-静息态功能磁共振成像研究

REGIONAL HOMOGENEITY IN KETAMINE DEPENDENCE:A RESTING-STATE FMRI STUDY

目的:探讨静息状态下氯胺酮依赖者的脑功能活动改变情况。方法:采用血氧水平依赖功能磁共振成像(BOLD-fMRI)技术,分析41例氯胺酮依赖者和44例与之相匹配的无任何物质依赖的健康志愿者静息状态下脑功能活动差异;采用局部一致性(ReHo)分析方法对数据进行处理。结果:与健康志愿者相比,氯胺酮依赖者静息状态下前扣带回BOLD信号ReHo降低(P<0.05,纠正后,cluster水平),额叶中央前回BOLD信号ReHo增强(P<0.05,纠正后,cluster水平)。额叶中央前回的ReHo值增加与总的氯胺酮使用量和对氯胺酮的渴求呈负相关。结论:首次采用ReHo方法分析了氯胺酮依赖者静息状态下脑的BOLD信号变化的脑区。此研究提示,氯胺酮依赖者额叶区功能活动存在异常。

Objective：To understand the resting-state brain activity of ketamine dependent subjects. Methods：Fouty one patients with ketamine dependence and 44 healthy control subjects were imaged with blood-oxygen-level dependence （BOLD） resting state functional magnetic resonance imaging （fMRI） and analysed with the regional homogeneity （ReHo） method. Results：Compared with healthy controls,decreased ReHo was found in ketamine users in the right anterior cingulated and increased ReHo was found in left frontal cortex （precentral gyrus） （P〈0.05,cluster-level corrected）. Negative correlations were found between increased ReHo in precentral frontal gyrus and estimated total lifetime ketamine consumption and ketamine craving levels. Conclusion：This is the first time to look for the changes of the resting-state brain activity in patients with chronic ketamine dependence. Our findings indicate that abnormal brain activity exists in frontal cortex in patients with ketamine dependence during resting state.