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妊娠期高血压疾病预测方法的对比研究

A contrast study on different predicting methods for hypertensive disorders complicating pregnancy
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摘要 目的 探讨6项指标联合预测孕妇发生妊娠期高血压疾病的临床可行性,了解其预报的灵敏度及特异度.方法 对妊娠14~28w的446名孕妇进行血β-绒毛膜促性腺激素、红细胞比容、平均动脉压、外周血管阻力、波形系数、体重指数共6项指标的测定.结果 6项指标联合阳性预测值为93.33%、阴性预测值为98.14%;6项指标联合预测组的阳性预测值明显高于其他各组,差异具有显著性(均P<0.05);无创检测(用妊娠期高血压疾病检测仪检测)联合血β-绒毛膜促性腺激素阳性预测值为57.69%、阴性预测值为98.33%;无创检测联合红细胞比容阳性预测值为64.00%、阴性预测值为98.57%;无创检测阳性预测值为64.29%,阴性预测值为99.04%,无创检测联合单项指标未能提高阳性预测值,差异无显著性(均P>0.05).结论 在基层医院应用检测仪即能较好的预测妊娠期高血压疾病,对妊娠期高血压疾病检测仪筛查出来的阳性孕妇再增加血β-绒毛膜促性腺激素、红细胞比容等6项指标联合预测,则可提高阳性预测值,更利于进行早期干预性治疗和围产期监护. Objective To investigate clinical feasibility of combined detections of human chorionic gonadotrophin (hCG), hematocrit (HCT), and measurement of mean arterial pressure (MAP), peripheral vascular resistance, waveform coefficient and body mass index (BMI) for predicting incidence of hypertensive disorders complicating pregnancy, and to compare its sensitivity and specificity with other predicting methods. Methods 446 pregnant women who were in 14-28 weeks of gestation were enrolled in the study. All of them were asked to detect serum hGG and HCT, or measure MAP, peripheral vascular resistance, waveform coefficient and BMI. Sensitivity, specificity and predictive values were calculated for each detection or measurement. Results The positive predictive value and negative predictive value of the combined predicting methods were 93.33% and 98. 14% respectively. The positive predictive value of the combined predicting methods was significantly higher than other predicting methods ( all P 〈 0.05 ). The positive predictive value and negative predictive value of noninvasive hypertensive disorder complicating pregnancy (HDCP) examination apparatus ( noninvassive method in brief) combined with serum detection of hCG were 57.69% and 98.33% respectively. The positive predictive value and negative predictive value of noninvasive method combined with detection of serum HCT were 64% and 98.57% respectively. The positive predictive value and negative predictive value of noninvasive method alone were 64.29% and 99.04% respectively. The noninvasive method combined with other single predicting methods failed to improve the positive predictive value, and there were no significant differences between the other groups ( all P 〉 0.05 ). Conclusion In local hospitals, noninvasive HDCP examination apparatus can better predict HDCP. The positive preditctive value could be improved if the combined six indexes predicting methods such as serum detection of 13-hCG and HCT combined with the noninvassive predicting methods are used for those positive pregnant women screened by the noninvassive predicting methods, which is more helpful to perform early interventive treatment and prenatal monitoring.
出处 《中国妇幼健康研究》 2010年第5期601-602,615,共3页 Chinese Journal of Woman and Child Health Research
关键词 妊娠期高血压疾病 阳性预测 阴性预测 方法 hypertensive disorders complicating pregnancy (HDCP) positive prediction negative prediction method
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参考文献7

  • 1崔秀娟,刘开华,张欣,徐行丽.血β-hCG、尿钙、Ca/Cr比值及平均动脉压联合预测妊高征的价值[J].现代妇产科进展,2000,9(3):193-194. 被引量:2
  • 2Juan Song,Song Zhang,Ye Qiao,et al.Predicting pregnancy-induced hypertension with dynamic hemodynamics[J].European Journal of Obstetrics & Gynecology and Reproductive Biology,2004,117(2):162-168.
  • 3Adsumelli R S,Elimian A,Wiencek V,et al.Change in pulse pressure during the preclinical phase of preeclampsia[J].J Reprod Med,2006,51(1):26-30.
  • 4Yaron Y,Ochshorn Y,Heifetz S,et al.First trimester maternal serum free human chorionic gonadotropin as a predictor of adverse pregnancy outcome[J].Fetal Diagn Ther,2002,17(6):352-356.
  • 5Chavarria M E,Lara G L,Gonz G A,et al.Maternal plasma cellular fibronectin concentrations in normal and preeclamptic pregnancies:A longitudinal study for early prediction of preeclampsia.[J].Am J Obstet Gynecol,2002,187(3):595-601.
  • 6Branch D W,Porter T F,Rittenhouse L,et al.Antiphosphplipid antibodies in women at risk for preeclampsia[J].Am J Obstet Gynecol,2000,184(3):825-832.
  • 7吴曼祯,陈文,陈秀华,黄远征,卢冬青.血β-绒毛膜促性腺激素、血钙、血细胞比容、平均动脉压在预测妊娠高血压综合征中的价值[J].中国全科医学,2006,9(4):295-296. 被引量:19

二级参考文献11

  • 1叶元华,戴淑真,耿新杰.尿钙检测对妊高征的预测价值[J].中华妇产科杂志,1995,30(11):668-669. 被引量:15
  • 2Chare Dong Hsu.Elevated serum human chorionic gonadotropin as evidence of secretory response in severe preeclampsia[J].AM J Obstet Gynecol,1994,170(2):1135.
  • 3Said MS.Beta-human chorionic gonadotropin levels before and after the development of preeclampsia[J].Br J Obstet Gynaecol,1984,91(2):772.
  • 4刘映舜.高危妊娠监护治疗学[M].北京:北京医科大学、中国协和医科大学联合出版社,1997.61.
  • 51,DekkerGA,SibaiBM.Earlydetectionofpreeclampsia.AmJObstetGynecol,1991,165:160
  • 62,HsuCD,ChanDW,LrigeB,etal.Elevatedserumhumanchorionicgonadotropinasevidenceofsecretoryresponseinseverepreeclampsia.AmJObstetGynecol,1994,170:1135
  • 73,GonenR,PerzR,DavidM,etal.Theassociationbetweenunexplainedsecond-trimestermaternalserumhCGelevationandpregnancycomplications.ObstetGynecol,1992,80:83
  • 8陈忻.中期妊娠mABP预测妊娠高血压[J].安徽医科大学学报,1986,21(1):49-49.
  • 9高坚蓉,高坚欣,李东红.钙代谢与妊高征的研究进展[J].国外医学(妇幼保健分册),2003,14(1):37-39. 被引量:4
  • 10郭华娟.妊娠期补充氨基酸螯合钙与妊高征的预防[J].中国误诊学杂志,2003,3(4):530-531. 被引量:3

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