我市283例药品不良反应报告分析

Analysis of 283 ADR Reports in Our City

目的:探讨药品不良反应(ADR)的发生规律,为临床合理用药及ADR的监测和预防提供参考。方法:对我市2010年1～6月收集到的283例ADR报告进行总结、分析。结果:在发生ADR的患者中,男性、女性性别构成比分别为50.18%、49.82%,无明显差别;年龄分布中,40～49岁年龄段构成比最大,为20.85%;引起ADR的药物以抗感染药为主,占62.90%,其中又以头孢菌素类常见(占抗感染药发生ADR总例数的42.13%);给药途径中静脉给药引起ADR的比例最高,占62.54%;累及器官或系统以皮肤及其附件损害为多见,占28.28%。结论:应加大ADR监测力度,及时通报ADR相关信息,提高医务人员的防范意识,促进临床合理用药,确保临床用药安全、有效。

OBJECTIVE：To analyze the regularity of ADR to provide reference for rational use of drugs in the clinic, ADR monitoring and prevention.METHODS：283 ADR cases collected from our city during Jan.～Jun.of 2010 were analyzed statistically.RESULTS：In ADR cases, the ratio of gender male and female was 50.18%、49.82%, there was no significant difference.The patients aged 40～49 years took up the biggest proportion, accounting for 20.85%.62.90% of ADR cases were caused by anti-infective agents （cephalosporin 42.13%）.62.54% were caused by intravenous administration.Main clinical manifestation of organs and system involved in ADR were lesion of skin and its appendant, accounting for 28.28%.CONCLUSION：Great importance should be attached to ADR monitoring to report the ADR cases.The awareness of prevention of medical staff should also be enhanced to promote rational use of drugs and ensure the safety and effectiveness of drug use.