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抑癌基因WWOX与恶性肿瘤的关系研究进展

Research Progress of the Relationship between WWOX Tumor Suppressor Gene and Malignant Tumors
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摘要 目的：探讨WW结构域氧化还原酶基因（WWOX）与肿瘤的关系,为临床提供理论依据.方法：在PubMed和中国期刊全文数据库中查阅近年来国内外有关文献,并做进一步综合分析.结果：WWOX位于人类普通型染色体脆性位点FRA16D上,在多种恶性肿瘤中表达下调或缺失,与WWOX作用相关的蛋白均处于信号转导的关键点.结论：WWOX可以增强多种抑癌基因的功能,抑制原癌基因的表达,从而发挥抑制肿瘤作用. Objective：To explore the relationship between WWOX gene and cancer, in order to provide a theoretical basis for the clinic. Methods：To look up latest related literatures in PUBMED and the Chinese Journals Full - text Database, then analyze the obtained data. Results ： WWOX gene is located at the fragile site 16D （FRA16D） of the common chromosome, it is down -regulated or absent in tumors, and the key points are the product of its expression in the signal transduetion pathways. Conclusions：WWOX gene can enhance the functions of multiple tumor suppressor genes and it plays a role in repression on oneogene expression.
作者 杨杰 马士崟
机构地区 蚌埠医学院第一附属医院头颈外科
出处 《解剖与临床》 2010年第5期379-381,共3页 Anatomy and Clinics
关键词 WWOX基因 脆性位点 抑癌基因 肿瘤 WWOX Fragile site Tumor suppressor gene Tumor
分类号 R730.2 [医药卫生—肿瘤]
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参考文献24

  • 1Ried K,Finnis M,Hobson L,et al.Common chromosomal fragile site FRA16D sequence:identification of the FORgene spanning FRA16D and homozygous deletions and trans-location breakpoints in cancer cells.HumMol Genet,2000,9(11):1651-1663.
  • 2Chang NS,Hsu LJ,Lin YS,et al.WW domain-containing oxidoreductase:a candidate tumor suppressor.Trends Mol Med,2007,13(1):12-22.
  • 3Bednarek AK,Lafl in KJ,Daniel RL,et al.WWOX,a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1,a region frequently affected in breast cancer.Cancer Res,2000,60(8):2140-2145.
  • 4Ludes-Meyers JH,Kil H,Bednarek AK,et al.WWOX bindsthe specific prolinerich ligand PPXY:identification of candidate interacting proteins.Oncogene,2004,23(29):5049-5055.
  • 5Chang NS,Pratt N,Heath J,et al.Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity.Biol Chem,2001,276(5):3361-3370.
  • 6Gourley C,Paige AJ,Taylor KJ,et al.WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant as atumour suppressor,although the role of variant4 remains unclear.Oncol,2005,26(6):1681-1689.
  • 7Watanabe A,Hippo Y,Taniguchi H,et al.An opposing view on WWOX protein function as a tumor suppressor.Cancer Res,2003,63(24):8629-8633.
  • 8Aqeilan RI,Donati V,Palamarchuk A,et al.WW domain-containing proteins,WWOX and YAP,compete for interaction with ErbB-4 and modulate its transcriptional function.Cancer Res,2005,65(15):6764-6772.
  • 9Ishii H,Momori K,Vecchione A,et al.Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes,FHIT and WWOX.Biochem Biophys Res commun,2004,316(4):1088-1093.
  • 10Iliopoulos D,Guler G,Han SY,et al.Fragile genes as biomarkers:epigenetic control of WWOX and FHIT in lung,breast and bladder cancer.Oncogene,2005,24(9):1625-1633.

二级参考文献77

  • 1李雯,徐永健,张珍祥.慢性阻塞性肺疾病患者气道上皮细胞阿米洛利敏感钠通道mRNA表达水平的研究[J].中华结核和呼吸杂志,2004,27(8):533-536. 被引量：6
  • 2Bednarek AK, Laflin K J, Daniel RL, et al. WWOX, a novel WW Domain-containing protein mappkng to human chromosome 16q23.3 - 24.1, a region frequently affected in breast cancer [ J ]. Cancer Res,2000,60(8) :2140 - 2145.
  • 3Aqeilan RI, Kuroki T, Pekarsky Y, et al. Loss of WWOX expression in gastric carcinoma [ J ]. Clin Cancer, 2004, 10 (9) : 3053 - 3058.
  • 4Gourley C, Paige AJ, Taylor KJ, et al. WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear[J]. Int J Chlcol,2005,26(6) : 1681 - 1689.
  • 5Pluciennik E, Kusinska R, Potemski P, et al. WWOX-the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis[J]. Eur J Surg Oneol,2006,32(2) :153 - 157.
  • 6Qin HR, Iliopoulos D, Semba S, et al. A role for the WWOX gene in prostate cancer[ J ]. Cancer Res, 2006,66 (13) : 6477 - 6481.
  • 7Donati V, Fontanini G,Dell'Omodarme M,et al, WWOX expression in different histologic types and subtypes of non-small cell lung cancer[J]. Clin Cancer Res,2007,13(3) :884 - 891.
  • 8Yendamuri S, Kuroki T, Trapasso F, et al. WW domain containing oxidoreductase gene expression is altered in non-small cell lung cancer[J]. Cancer Res,2003,63(4) :878 - 881.
  • 9Zhou Y,Xu Y,Zhandg Z. Detion and mutation of WWOX exons 6- 8in human non-small cell lung cancer. J Huazhong Univ Sci Technolog Med Sci,2005,25(2) : 162 - 165.
  • 10Hoffman PC, Mauer AM, Vokes EE. Lung cancer [ J]. Lancet, 2000,355 (9202) : 479 - 485.

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