哮喘急性发作期血清超敏C-反应蛋白测定的临床意义

Clinical significance of the determination of serum high-sensitivity C-reactive protein in the patients with asthma at acute stage

目的探讨支气管哮喘急性发作期患者血清超敏C反应蛋白(HsCRP)水平变化和临床意义。方法运用免疫比浊法测定72例支气管哮喘急性发作期患者(哮喘组)治疗前后血清HsCRP水平变化,同时测定血常规和肺功能,另选31例健康者作为对照组进行比较。结果支气管哮喘急性发作期患者治疗前HsCRP水平显著高于对照组(P<0.01),治疗后HsCRP水平显著低于治疗前(P<0.01),但仍明显高于对照组(P<0.05)。结论血清HsCRP水平可作为评估支气管哮喘急性发作期患者病情的一个炎性指标。

Objective To observe the levels of serum high-sensitivity C-reactive protein （HsCRP） in patients with asthma at acute stage and to investigate its clinical significance. Methods Totally 72 patients with asthma at acute stage（ treated group） and 31 healthy volunteers（ control group） were included in this study. HsCRP in the pa- tients was measured before and after treatment, and HsCRP in control group was also measured. At the same time, blood routine and pulmonary function were examinated. Results HsCRP levels of the patients before treatment was significantly higher than that of controls （P 〈 0. 01 ）. After treatment, HsCRP levels of the patients was significantly lower（P 〈 0. 01 ）, being still significantly higher than that of control group （P 〈 0. 05 ）. Conclusion HsCRP levels can be used as an inflammatory index for evaluation of patient＇ s condition.