摘要
目的调查镇江地区112例胃癌患者环氧化酶2(COX-2)、p53和生存素的表达。方法用半定量RT-PCR法检测COX-2和生存素的表达,免疫组化检测p53的表达。结果 COX-2、p53基因和生存素在胃癌组织中的阳性表达率均明显高于相应的癌旁组织和正常组织(P<0.01),且在低分化的胃腺癌中的阳性表达率高于中高分化类型的胃腺癌(P<0.01或P<0.05)。结论 COX-2、p53和生存素与胃癌的发生相关;检测三种胃癌相关基因可以判断肿瘤的预后。
Objective To investigate the expressions of cyclooxygenase-2（COX-2）,p53 and survivin in gastric cancer and tumor-adjacent tissues in 112 patients.Methods The expressions of COX-2 and survivin were detected by semiquantitate RT-PCR and the expression of p53 by immunohistochemistry. Results The positive expressions of COX-2,p53 and survivin were all significantly higher in gastric cancer tissue than those in the tumor-adjacent and normal gastric tissues（P0.01）,which were significantly higher in the poorly differentiated gastric adenocarcinoma than those in the well-differentiated cancer tissue（P0.01 or P0.05）.Conclusion COX-2,p53 and survivin are correlated with the development of gastric cancer,detection of which may predic the prognosis of the patients with gastric cancer.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第18期2139-2142,共4页
Jiangsu Medical Journal
基金
江苏大学临床医学科技发展基金(JLY20080019)
