人直肠癌中血管内皮生长因子受体3的表达及其意义

Expression and significance of VEGFR-3 in human rectal adenocarcinoma

目的探讨血管内皮生长因子受体3(VEGFR-3)在人直肠癌发生、发展和淋巴结转移中的作用。方法选用31例手术切除并经病理切片确诊为直肠腺癌的癌组织及其中的14例淋巴结(9例腺癌转移阳性,4例腺癌转移阴性)石蜡标本,采用免疫组织化学方法检测VEGFR-3在癌组织和淋巴结内的表达。结果 31例直肠腺癌组织的癌细胞质中,VEGFR-3显色阳性者20例(64.5%)。14例淋巴结中,VEGFR-3显色阳性者9例(64.3%,4例显色于无腺癌转移淋巴细胞内)。结论 VEGFR-3在直肠癌组织和淋巴结中均有较高表达,可促进癌细胞转移。

Objective To study the role of expression of vascular endothelial growth factor receptor-3（VEGFR-3） in rectal adenocarcinoma tissue and lymph nodes.Methods The expression of VEGFR-3 was detected in 31 paraffin-embedded cases of rectal adenocarcinoma tissue and 14 paraffin-embedded cases of lymph nodes using immunohistochemistry method.Results Of 31 cases of rectal adenocarcinoma,VEGFR-3 positive expression was detected in 20 cases（64.5%）.VEGFR-3 was positively expressed in 9 cases（64.3%） of 14 lymph nodes,in which 5 lymph nodes were with adenocarcinoma metastasis and 4 without.Conclusion VEGFR-3 was highly expressed in rectal adenocarcinoma tissues and lymph nodes with and without adenocarcinoma metastasis,which promotes metastasis of the adenocarcinoma.