骨髓间充质干细胞与运动性脊髓损伤

Bone marrow mesenchymal stem cells and sports spinal cord injury

背景:骨髓间充质干细胞移植对于运动性脊髓损伤是一种有效的治疗手段。但目前有关脊髓损伤的研究尚不充分,且缺乏对其机制及其良好治疗方法的探讨。目的:通过分析运动性脊髓损伤的病理特征、骨髓间充质干细胞的生理特性,及其运用于脊髓损伤的应用,为制定运动性脊髓损伤的康复治疗方案提供理论依据和科学支撑。方法:应用计算机检索Pubmed数据库(1991/2010),以"Mesenchymal stem cell,sports Kneeinjuries"为检索词;应用计算机检索维普数据库(1991/2010),以"骨髓间充质干细胞、运动性脊髓损伤"为检索词。结果与结论:共收集到85篇文献,排除发表时间较早、实验设计科学性较差的文献,共25篇文献符合标准被纳入。骨髓间充质干细胞能分化为神经元样细胞,反应性分泌各种营养因子及生长因子,以增强神经的保护作用和促进局部微血管再生,从而起到治疗脊髓损伤的作用。但运动性脊髓损伤后损伤部位的缺血、缺氧、运动性自由基的产生及兴奋性氨基酸等影响骨髓间充质干细胞分化及其结果的相关问题仍需要大量的实验研究予以一一证实。

BACKGROUND：Bone marrow mesenchymal stem cell transplantation is an effective method to treat exercise-induced spinal cord injury （SCI）.However, the study concerning SCI is not enough, and lacks of exploration of its mechanism and good therapeutic methods.OBJECTIVE：To provide theoretical basis and scientific support for rehabilitation treatment programs of exercise-induced SCI by analysis of pathological features of exercise-induced SCI, physiological characteristics of bone marrow mesenchymal stem cells and its application to SCI.METHODS：We searched Pubmed database （1991/2010） with the key wrds of ＂mesenchymal stem cell, sports knee injuries＂.VIP database was searched （1991/2010） with the key wrds of ＂bone marrow mesenchymal stem cell, sports knee injuries＂.RESULTS AND CONCLUSION：A total of 85 literatures were retrieved, and those published early or with poor quality were excluded.Finally, 25 literatures were included.Bone marrow mesenchymal stem cells were divided into neuron-like cells, reactive secretion of various nutrition factors and growth factors to promote neuroprotective effect and promote local microvessel regeneration, resulting in treating SCI.However, related problems that affected the differentiation and its results of bone marrow mesenchymal stem cells such as ischemia, hypoxia and production of sports free radical and excitatory amino acids following exercise-induced SCI in the injury region require further investigations.