关节软骨的缺损与修复

Defects and repair of articular cartilage

背景:关节软骨自身修复能力有限,一旦受损,难于恢复。目的:概述目前关节软骨缺损的主要临床治疗手段及发展趋势。方法:以articular cartilage,cartilage defects,treatment为检索词,检索PubMed数据库(1995-01/2010-06),文献检索语种限制为英文。排除与软骨损伤的修复重建相关性不强、以及内容重复、陈旧的文献。共保留32篇文献进行综述。结果与结论:目前关节软骨缺损的临床治疗手段包括微骨折术、自体骨软骨移植术、异体骨软骨移植术、自体软骨细胞移植术等,这些方法通常能有效地缓解临床症状,已经被众多学者接受,但仍然存在一些亟待解决的问题。与这些已经投入临床的技术相比,利用组织工程化软骨修复关节软骨缺损是一项新技术,由于其出现时间较短,技术尚未成熟,与其相关的临床研究仍在不断进行。

BACKGROUND：Articular cartilage has a poor intrinsic capacity for healing,once damaged from trauma or degeneration,it is hard to repair.OBJECTIVE：To concisely describe the common current treatment of articular cartilage defects and the future trend.METHODS：A search across the databases of PubMed（January 1995 to June 2010） was performed,with key words of ＂articular cartilage,cartilage defects,treatment＂.The language was limited for English.The repetitive studies or unrelated to papers the objective were excluded.A total of 32 papers were included in this study.RESULTS AND CONCLUSION：Microfracture,autologous osteochondral transplantation,osteochondral allograft transplantation,and autologous chondrocyte implantation were common used for repairing articular cartilage defects.Usually,these strategies could relieve clinical symptoms effectively,but there are problems need to be solved.Compared with those techniques,cartilage tissue engineering is a new strategy for cartilage repair emerging in recent years,and many studies about it are still ongoing.