甲壳素/壳聚糖生物抗菌敷料在皮肤组织工程中的应用

Application of chitin/chitosan biological antimicrobial dressing in skin tissue engineering

目的:探讨甲壳素/壳聚糖生物抗菌敷料的性能及其在皮肤组织工程中的应用。方法:由作者应用计算机检索中国知网(CNKI)与万方医学网中与生物抗菌敷料特性及临床应用有关的文献,检索时限为1996/2010。检索关键词:生物抗菌敷料,甲壳素/壳聚糖,皮肤组织工程,安全性,性能特点。纳入标准:①甲壳素/壳聚糖生物抗菌敷料的性能。②甲壳素/壳聚糖生物抗菌敷料在皮肤组织工程中的应用。③同一领域选择近期发表或在权威杂志上发表的文章。排除标准:排除重复研究和较陈旧文献。对资料进行初审,并查看每篇文献后的引文。结果:根据纳入排除标准,共纳入20篇相关文献。甲壳素/壳聚糖安全性和可降解性良好,吸湿性、抑菌性强,并具有止血和止痛、抑制瘢痕形成、促进细胞生长、加速伤口创面愈合和促进机体非特异性免疫的功能。从其在皮肤组织工程中的应用研究来看,甲壳素/壳聚糖可有效促进烧伤创面的愈合和皮肤再生,且不增加创面感染的机率。结论:甲壳素/壳聚糖生物抗菌敷料性能良好,能有效促进烧伤创面愈合和增强皮肤再生,在皮肤组织工程及其他医学领域中具有广泛常规应用的可能性。

OBJECTIVE： To investigate the performance of chitin/chitosan biological antimicrobial dressings and their application in skin tissue engineering. METHODS： China CNKI and Wangfang Medical network were searched on computer for articles about characteristics and clinical application of biological antibacterial dressings, retrieval time is from 1996 to 2010. Key words： biological antirnicrobial dressings, chitin/chitosan, skin tissue engineering, security, performance in Chinese. Inclusion criteria： ①characteristics of chitin/chitosan biological antimicrebial dressings.② application of chitin/chitosan biological antimicrobial dressing in skin tissue engineering. ③ articles recently published or published in the authority journals were preferred in the same field. Exclusion criteria： duplicated research and older literature were excluded. All data were checked preliminarily, and citations after each article were looked over. RESULTS： According to the inclusion and exclusion criteria, 20 articles were included in the review. Chitin/chitosan has good security and degradation, strong moisture absorption and antibacterial property, it stops bleeding and pain, inhibits scar formation promotes cell growth, accelerates wound healing and promotes non-specific immune function. From the application in skin tissue engineering research, chitin/chitosan is effective in promoting burn wound healing and skin regeneration, the probability of wound infection is not increasing. CONCLUSION： Chitin/chitosan biological antirnicrobial dressing has good performance, can effectively promote the burn wound healing and enhance skin regeneration, has a broad general application possibility in skin tissue engineering and other fields of medicine.