男性2型糖尿病患者骨密度研究

Study of bone mineral density in male type 2 diabetes

目的探讨男性2型糖尿病与骨质疏松的关系。方法采用美国Norland双能X线骨密度检测仪对22例男性2型糖尿病(T2DM)患者及25例健康体检者进行腰椎L2-L4和左侧股骨近端(包括Neck、Troch、Ward三角区)骨密度测定,并测定空腹血糖(FBG)、糖化血红蛋白(HbAlc)、甘油三脂(TG)、胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C),结合年龄、病程、体重指数(BMI)等因素进行研究。结果糖尿病组患者空腹血糖9.89±3.27mmol/L、糖化血红蛋白8.24±1.43、甘油三脂2.27±1.41mmol/L、低密度脂蛋白2.88±0.91mmol/L较正常对照组空腹血糖5.60±1.00mmol/L、糖化血红蛋白4.62±0.68、甘油三脂1.32±0.86mmol/L、低密度脂蛋白2.28±1.06mmol/L显著增高(P<0.05);糖尿病患者Neck、Ward三角区、Troch的骨密度分别为0.88±0.21g/cm2、0.63±0.11g/cm2、0.73±0.08g/cm2均低于正常对照组的1.02±0.06g/cm2、0.76±0.14g/cm2、0.83±0.09g/cm2,具有显著统计学意义(P<0.05),而腰椎骨密度1.06±0.20g/cm2与正常人1.17±0.14g/cm2相比无明显差异(P>0.05)。结论男性2型糖尿病患者更易发生骨质疏松,骨折的危险性也高于正常人,早期筛查血糖及骨密度具有重要意义。

Objective To explore the relationship between male type 2 diabetes and osteoporosis. Methods Bone mineral densities （BMDs） of lumbar vertebra 2-4 （ L2-L4 ） and the proximal region of left femur including neck, Troeh, and Ward triangle were detected using dual energy X-ray absorptiometry （DEXA） in 22 male type 2 diabetes patients and 25 healthy people. Meanwhile, the serum levels of FBG, HbAIc, TG, TC, HDL-C, LDL-C were also measured and analyzed combined with factors including age, course of disease, and body mass index. Results The serum levels of FBG, HbAlc, TG, and LDL-C in the diabetic patients were 9.89 ± 3.27mmol/L, 8.24 ± 1.43mmol/L, 2.27 ± 1.41mmol/L, and 2.88 ± 0.91mmol/L, respectively, which were significantly higher than those in the control group people （5.6 ± 1.00mmol/L, 4. 62 ±0. 68mmol/L, 1.32 ±0. 86mmol/L, and 2.28 ± 1.06mmol/L, respectively, P 〈 0. 05）. The BMDs of the neck, Ward triangle, and Troeh area in the diabetic patients were 0. 88±0.21mmol/L, 0.63 ± 0.11 mmol/L, and 0. 73 ± 0.08mmol/L, respectively, which were significantly lower than those in the control group people （ 1.02 ± 0.06mmol/L, 0.76 ± 0. 14mmol/L, and 0. 83 ± 0.09mrnol/L, respectively, P 〈 0. 05）. The BMDs of the lumbar vertebra in the diabetic patients were 1.06 ± 0.20mmol/L, which were no significantly difference compared with those in the control group people （ 1.17 ± 0.14mmol/L, P 〉0.05）. Conclusion Male patients with type 2 diabetes are much easier to get osteoporosis. The bone fracture risk of those patients is higher than that of heathy people. The early screening of serum glucose and bone mineral density is of significance.