锝[99Tc]-亚甲基双膦酸盐治疗老年女性绝经后骨质疏松症中的疗效观察

The observation of effect of technetium [99Tc] methylenediphosphonate treatment on elderly women with postmenopausal osteoporosis

目的探讨锝[99Tc]-亚甲基双膦酸盐(云克)治疗老年女性绝经后骨质疏松症的疗效和安全性。方法用云克治疗126例老年女性绝经后骨质疏松症,观察治疗前后的临床表现及实验室检查指标,髋关节骨密度(BMD,血清骨钙素(BGP,和尿吡啶酚(PYD的变化。结果该药有效率为92.9%,可显著增加骨密度(P<0.05〉,骨代谢指标尿吡啶酚降低(P<0.05)和血清骨钙素升高(P<0.05)。结论锝[99Tc]-亚甲基双膦酸盐疗效明显,使用安全,无明显的副作用,值得临床广泛推广使用。

Objective To explore the efficacy and safety of technetium [ 99Tc] methylenediphosphonate （Yunke） treatment for the elderly women with postmenopausal osteoporosis. Methods One hundred and twenty-six elderly women with postmenopausal osteoporosis were treated with Yunke. Clinical manifestation and laboratory examination data were collected and analyzed before and after the treatment, including bone mineral density （BMD） of the hip, osteoealcin （BGP） , and urinary pyridinoline （PYD）. Results The total effective rate of this drug was 92.9%. The drug could increase BMD and BGP and decrease PYD significantly （P 〈 0.05）. Conclusion Technetium [ 99Tc ] methylenediphosphonate is an effective and safe therapy without obvious side effects and should be widely applied in the clinic.