骨折实验动物模型研究进展

Progress in the experimental animal bone fracture model research

骨折实验动物模型作为一种实验平台已经被广泛地应用于临床前研究,用来说明和阐述骨折的各种生理及病理过程的特征,以及用来探索可以改变生物学及生物力学的新的特殊方法。在研究中,实验动物模型的选择需要进行人工干预,所使用的实验动物模型应该是特征清晰的、建立了对照组数据并且能够被重复试验的,只有这样,所得到的结果才能与其他类似的研究进行可靠的定量和定性的比较。本文的目的是通过讨论在骨折愈合研究中所使用的不同类型的实验动物模型,就适用条件描述它们的特征,并为实验动物模型的选择提供方向。

Experimental animal bone fracture models have been extensively applied as platforms for preclinical research to explain and illustrate the physiological and pathological characters of the bone fracture and to explore new specific maneuvers which can alter the biology and biomechanics of bone. The experimental animal models selected for research should be employed for artificial intervention. The experimental animal models used should be clearly characterized, control group established, and the experiments could be reproduced. By these, the results produced can be compared reliably with other similar studies quantitatively and qualitatively. The aim of this review is to describe the characteristics of the experimental animal bone fracture models applied in diverse fracture healing research and to provide selection guidance of experimental animal models.