Robin序列征37例临床研究

Robin Sequence:Retrospective Analysis of 37 Cases

目的:通过对37例Robin序列征患儿进行全身及局部特有临床症状的观察,并与单纯性腭裂患儿进行对比,浅析Robin序列征患儿的全身营养及局部气道情况,为喂养及围手术期提供具有临床意义的参考指标,从而有效地减少手术风险。方法:2009-05—2010-04于本唇腭裂治疗中心就诊的Robin序列征患儿37例,全面回顾其病史并进行体格检查,观察各种畸形及并发症的发生率,根据同龄正常婴幼儿的各项数值对患儿的全身情况进行客观评价,并与单纯性腭裂患儿进行比较。结果:病例组与对照组儿童全身营养情况(身长、体重、BMI指数)总体上差异无统计学意义(P>0.05),但是12个月以下的Robin序列征患儿的体重及BMI指数与对照组差异有高度统计学意义(P<0.01);病例组与对照组在鼾症、呛咳、吸入性肺炎的发生率及睡姿方面的差异存在高度统计学意义(P<0.01);Robin序列征患儿最常见的伴发畸形分别是漏斗胸、舌系带过短及卵圆孔未闭。结论:12个月以上的患儿全身情况可以接受腭裂修复手术;Robin序列征患儿较单纯性腭裂患儿更易发生鼾症、呛咳、吸入性肺炎等,且更易伴有全身的其他畸形。

Objective： To provide a reference index for feeding and surgery of patients with Robin Sequence by evaluation on general and local symptoms of 37 patients. Methods： A total of 37 patients with Robin Sequence treated in cleft lip and palate center, Shanghai Ninth People＇s Hospital Affiliated to Shanghai Jiaotong University School of Medicine from May 2009 to April 2010 were retrospectively reviewed. Data was regarded as age, gender, weight, height, BMI, medical history and clinical symptoms. Results： No significant differences were showed comparisons of height, weight and BM] between Robin Sequence cases and controls. Patients under 12 months are statistically different from control group.The incidences of snore, cough during feeding and inhalation pneumonia and sleeping position were significantly different between two groups. The most common associated deformities were chonechondrosternon, ankyloglossum and acleistocardia. Conclusion： General condition of patients with Robin Sequence above the age of 12 months can undergo cleft palate repair. Patients with Robin Sequence are more likely to have snore, cough during feeding and inhalation pneumonia than patients with isolated cleft palate.