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人脑胶质瘤组织CD105的表达及意义 被引量：1

Expression of CD105 in human glioma tissues and its significance
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摘要 目的探讨人脑胶质瘤组织CD105 mRNA和蛋白的表达及意义。方法应用组织芯片结合免疫组化技术检测152例脑胶质瘤(WHOⅠ级4例,Ⅱ级32例,Ⅲ级68例,Ⅳ级48例)与20例正常脑组织中CD105蛋白的表达;应用实时荧光定量PCR技术研究22例胶质瘤(Ⅱ级7例,Ⅲ～Ⅳ级15例)与4例正常脑组织中的CD105 mRNA表达。所得结果采用秩和检验、t′检验。结果脑胶质瘤组CD105mRNA表达高于正常组(P=0.0322),Ⅲ～Ⅳ级组高于Ⅱ级组(P<0.05)。CD105标记的微血管密度(MVD)在Ⅲ～Ⅳ级组高于Ⅰ～Ⅱ级组(P<0.05),Ⅰ～Ⅱ级组高于正常组(P<0.05)。结论人脑胶质瘤组织CD105 mRNA在转录水平已上调,CD105的表达与胶质瘤病理分级有关。
作者 徐舒 岳志健 周晓平 王建军 王来兴 刘建民
机构地区 南京中医药大学附属常州市中医医院神经外科 第二军医大学长海医院神经外科 第二军医大学长海医院病理科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第10期1152-1154,共3页 Academic Journal of Second Military Medical University
关键词 神经胶质瘤 CD105 微血管密度 免疫组织化学 组织芯片 聚合酶链反应
分类号 R739.41 [医药卫生—肿瘤]
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参考文献14

  • 1Wikstrom P, Lissbrant I F,Stattin P,Egevad I., Bergh A. Endoglin (CD105) is expressed on immature blood vessels and is a marker for survival in prostate cancer[J]. Prostate, 2002,51: 268 -275.
  • 2Fonsatti E,Jekunen A P, Kairemo K J, Coral S, Snellman M, Nicotra M R,et al. Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model-J-. Clin Cancer Res, 2000,6 : 2037- 2043.
  • 3Benetti A, Berenzi A, Gambarotti M, Garrafa E, Gelati M, Dessy E,et al. Transforming growth factor-betal and CD105 promote the migration of hepatocellular carcinoma derived endothelium [J-. Cancer Res,2008,68:8626- 8634.
  • 4Chiba H,Ishii G,Ito T K,Aoyagi K,Sasaki H,Nagai K,et al. CD105-positive cells in pulmonary arterial blood of adult human lung cancer patients include mesenchymal progenitors[J]. Stem Ceils, 2008,26:2523- 2530.
  • 5Oxmann D, Held-Feindt J, Stark A M, Hattermann K, Yoneda T,Mentlein R. Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype[J]. Oneogene, 2008,27 : 3567 -3575.
  • 6Svatek R S, Karam J A, Roehrborn C G, Karakiewicz P I, Slawin K M, Shariat S F. Preoperative plasma endoglin levels predict biochemical progression after radical prostatectomy [J]. Clin Cancer Res,2008,14:3362 -3366.
  • 7Sandlund J,Hedberg Y, Bergh A, Grankvist K, Ljungberg B, Rasmuson T. Endoglin (CD105) expression in human renal cell carcinoma[J]. BJU Int, 2006,97 :706 -710.
  • 8Chien C Y,Su C Y, Hwang C F,Chuang H C,Hsiao Y C,Wu S L,et al. Clinieopathologic significance of CD105 expression in squamous cell carcinoma of the hypopharynx[J]. Head Neck, 2006,28:441- 446.
  • 9王艳芬,丁永玲,李家驭,周晓明.Ang-2、CD105和CD34在脑胶质瘤中的表达及生物学意义[J].现代肿瘤医学,2008,16(1):23-26. 被引量：12
  • 10Tanaka F, Otake Y, Yanagihara K, Kawano Y, Miyahara R, Li M,et al. Correlation between apoptotic index and angiogenesis in non small cell lung cancer: comparison between CD105 and CD34 as a marker of angiogenesis[J]. Lung Cancer, 2003,39: 289-296.

二级参考文献10

  • 1饶娅敏,陈同钰.HIF-1α、COX-2、VEGF与胶质瘤[J].现代肿瘤医学,2006,14(2):145-147. 被引量：7
  • 2谷金宇,吕雪莹,李大林,任欢.缺氧诱导结直肠癌细胞Ang-2的表达[J].中国肿瘤临床,2006,33(14):802-804. 被引量：6
  • 3Ward EG, Grosios K, Markham AF, et al. Genomie structure of the human angiopoietins show polymorphism in angiopoietin - 2 [ J ]. Cytogenet Cell Genet,2001,94 ( 3 ) : 147-154.
  • 4Holash J, Maisonpierre PC, Compton D, et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF [ J ]. Science, 1999,284 ( 5422 ) : 1994 - 1998.
  • 5Hawighorst T, Skobe M, Streit M, et al Activation of the Tie2 receptor by angiopoietin - 1 enhances tumor vessel maturation and impairs squamous cell carcinoma growth [ J ]. Am J Pathol, 2002, 160(4) :1381 - 1392.
  • 6Ochiumi T, Tanaka S, Oka S, et al. Clinical significance of angiopoietin - 2 expression at the deepest invasive tumor site of advanced colorectal carcinoma[ J]. Int J Oncol,2004,24:539-547.
  • 7Wikstrom P, Lissbrant IF, Stattin P, et al. Endoglin ( CD105 ) is expressed on immature blood vesels and is a marker for survival in prostate cancer [ J ]. Prostate,2002,51 ( 4 ) : 268 - 275.
  • 8Koga K ,Todaka T, Morioka M, et al. Expression of angiopoietin -2 in human glioma cells and its role for angiogenesis [ J ]. Cancer, 2001,61 (16) :6248 -6254.
  • 9Takahashi A, Kono K, Itakura J,et al. Correlation of vascular endothelial growth factor - expression with tumor - infiltrating dentritic ceils in gastric cancer[ J]. Oncology,2002,62(2) : 121 - 127.
  • 10Ogawa M, Yamamoto H. Hepatic expression of Ang-2 RNA in metastatic colorectal cancer[ J ]. Hepatology, 2004,39 (2) :528-539.

共引文献11

同被引文献21

  • 1王玥,刘爱东,庞久玲,刘悦,刘昌岭.CD_(105)在结直肠腺癌组织中的表达及意义[J].山东医药,2007,47(20):27-27. 被引量：17
  • 2DALLAS NA,SAMUEL S,XIA L,et al.Endoglin (CD105):a marker of tumor vasculature and potential target for therapy[J].Clin Cancer Res,2008,14(7):1931-1937.
  • 3DING S,LI C,LIN S,et al.Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions[J].Hum Pathd,2006,37(7):861-866.
  • 4OTTONELLO L,GHIO M,CONTINI P,et al.Nonleukoreduced red blood cell transfusion induces a sustained inhibition of neutrophil chemotaxis by stimulating in vivo production of transforming growth factor-beta1 by neutrophils:role of the immunoglobulinlike transcript1,sFasL,and sHLA-Ⅰ[J].Transfusion,2007,47(8):1395-1404.
  • 5CASTONGUAY R,WERNER ED,MATTHEWS RG,et al.Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain,inhibits blood vessel formation,and suppresses tumor growth[J].J Biol Chem,2011,286(34):30034-30046.
  • 6WOOD LM,PAN ZK,GUIRNALDA P,et al.Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105[J].Cancer Immunol Immunother,2011,60(7):931-942.
  • 7TOMULEASA C,SORITAU O,RUS-CIUCA D,et al.Functional and molecular characterization of glioblastoma multiforme-derived cancer stem cells[J].J Buon,2010,15(3):583-591.
  • 8MA YH,MENTLEIN R,KNERLICH F,et al.Expression of stem cell markers in human astrocytomas of different WHO grades[J].J Neurooncol,2008,86(1):31-45.
  • 9KAPOOR GS,GOCKE TA,CHAWLA S,et al.Magnetic resonance perfusion-weighted imaging defines angiogenic subtypes of oligodendroglioma according to 1p19q and EGFR status[J].J Neurooncol,2009,92(3):373-386.
  • 10ZHANG D,FENG XY,HENNING TD,et al.MR imaging of tumor angiogenesis using sterically stabilized Gd-DTPA liposomes targeted to CD105[J].Eur J Radiol,2009,70(1):180-189.

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第二军医大学学报
2010年 第10期

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