联合应用细胞学检查与P53蛋白检测提高甲状腺癌术前诊断率

Elevating the ratio of preoperative diagnosis of thyroid cancer by combined application of fine-needle aspiration cytology and P53 protein detection

目的研究细针穿刺细胞学与P53蛋白检测联合应用,以提高甲状腺癌术前诊断的准确率。方法收集术前进行细针穿刺作细胞学检查和免疫组织化学法(S-P)作P53蛋白表达检测的甲状腺肿瘤患者40例,联合二者的结果对甲状腺癌的术前诊断率进行研究。结果 40例中经术后病理诊断为甲状腺癌的为28例;术前经细胞学检查诊断为甲状腺癌的为23例,P53蛋白检测阳性的为16例,二者的灵敏度分别为82.14%和57.14%,细胞学与P53蛋白联合检测的灵敏度为92.86%。结论术前经细针穿刺作细胞学检查联合P53蛋白检测可以提高甲状腺癌的术前诊断率。

Objective To study on the combined application of the fine-needle aspiration cytology and P53 protein detection in order to improve the accuracy of preoperative diagnosis of thyroid cancer.Methods Preoperative the fine-needle aspiration detection of cytology and P53 protein expression using immunohistochemical（S-P）method were performed in 40 patients with thyroid neoplasm,preoperative diagnosis rate of thyroid cancer was studied by the joint results of both.Results In 40 cases,28 positive cases of thyroid cancer were measured by pathological diagnosis;23 positive cases of thyroid cancer were measured by preoperative cytological diagnosis,the 16 positive cases of thyroid cancer were measured by the P53 protein testing.The sensitivities of the two methods were 82.14% and 57.14%,respectively.The sensitivity of combined detection of the two methods was 92.86%.Conclusion The preoperative fine-needle aspiration cytology combined with P53 protein detection can improve the preoperative diagnosis rate of thyroid cancer.