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P糖蛋白介导的寄生虫抗药性及其逆转的研究进展 被引量：5

Advances in P-glycoprotein-mediated anthelmintic resistance and its reversal in parasites
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摘要 从ABC转运蛋白家族、编码P糖蛋白(Pgp)基因、Pgp检测方法、Pgp与驱虫药的抗药性、Pgp介导的药物转运机制及其抗药性逆转、RNA干扰技术抑制或沉默Pgp基因表达等方面综述了Pgp介导的寄生虫抗药性及其逆转的研究进展,为将来解决寄生虫抗药性问题奠定基础。 Advances in P-glycoprotein（Pgp）-mediated anthelmintic resistance and its reversal in parasites were reviewed on family of ATP-binding cassettes,Pgp genes,detection methods of Pgp,roles of Pgp in anthelmintic resistance,mechanism in anthelmintic efficacy and reversal of drug resistance due to modulation of Pgp activity,suppression and silencing of Pgp expression by RNA interference,in order to offer the foundation for studying the mechanism of drug resistance in parasites in future.
作者 柏家林 蔡葵蒸 何进全
机构地区 西北民族大学生命科学与工程学院 甘肃省动物细胞工程技术研究中心 西北民族大学医学院
出处 《中国兽医科学》 CAS CSCD 北大核心 2010年第10期1085-1092,共8页 Chinese Veterinary Science
关键词 寄生虫 P糖蛋白 驱虫药抗药性 抗药性逆转 parasite P-glycoprotein anthelmintic resistance reversal of drug resistance
分类号 S852.7 [农业科学—基础兽医学] S859.795 [农业科学—临床兽医学]
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参考文献76

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二级参考文献26

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中国兽医科学
2010年 第10期

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