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microRNA与动脉粥样硬化炎症反应 被引量：4

MicroRNAs in the Inflammation of Atherosclerosis
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摘要 microRNAs的发现是近年来生物学研究上的重要突破之一。随着研究的深入,证实了microRNA参与了免疫介导性疾病的发生发展。动脉粥样硬化是免疫介导性动脉血管壁慢性炎症,这将使得microRNA将可能成为动脉粥样硬化炎症反应研究的热点。本文综述了microRNA在调控炎症细胞的发育、分化及功能中的作用,与炎性细胞因子调控密切相关的microRNA,最后综合阐述了microRNA与动脉粥样硬化炎症反应的关系。 The discovery of microRNAs is a major breakthrough of biological research in recent years.With the rapid progress in the field,microRNAs have been confirmed to be involved in flammation and immune-mediated disease.Since in ammation is clearly a key event for the initiation and progression of atherosclerosis,microRNAs is becoming the research hotspot on revealing the explicit mechanism of atherosclerosis and developing new therapeutic strategies for vascular diseases.This article described the investigation progress on how microRNAs modulate the inflammatory cells differentiation and function,and then showed the role of specific microRNAs on inflammatory cytokines.In the end,we addressed the contribution of microRNAs for vascular in ammation involved in atherosclerosis.
作者 陈妍梅 李浪
机构地区 广西医科大学第一附属医院心血管内科
出处 《中国动脉硬化杂志》 CAS CSCD 北大核心 2010年第8期662-664,668,共4页 Chinese Journal of Arteriosclerosis
基金 国家自然科学基金(30760262)
关键词 MICRORNAS 动脉粥样硬化 炎症细胞 炎性细胞分子 MicroRNAs Atherosclerosis Inflammatory Cells Inflammatory Molecules.
分类号 R363 [医药卫生—病理学]
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参考文献22

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同被引文献52

  • 1姚晓敏,宋保亮,王灿华,张文静,林志新,李伯良.人酰基辅酶A:胆固醇酰基转移酶(ACAT)[J].上海交通大学学报（农业科学版）,2006,24(1):108-115. 被引量：13
  • 2Andersson J, Libby P, Hansson GK. Adaptive immunity and atherosclerosis [ J]. Clin Immunol, 2010, 134 ( 1 ): 33-46.
  • 3Kim VN. Small RNAs: classification, biogenesis and func- tion [J]. nol Cells, 2005, 19(1): 1-15.
  • 4Shimada K. Immune system and atherosclerotic disease: heterogeneity of leukocyte subsets participating in the path- ogenesis of atherosclerosis [ J ]. Circ J, 2009, 73 (6) : 994-1 001.
  • 5Shivdasani RA. MicroRNAs: regulators of gene expression and cell differentiation [ J ]. Blood, 2006, 108 (12) : 3 646-653.
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  • 7Banerjee A, Schambach F, DeJong CS, et al. Micro-RNA- 155 inhibits IFN-gamma signaling in CD4 + T cells [ J]. Eur J Immunol, 2010, 40( 1 ) : 225-231.
  • 8Rodriguez A, Vigorito E, Clare S, et al. Requirement of bic/microRNA-155 for normal immune function [ J]. Sci- ence, 2007, 316(5824): 608-611.
  • 9Rouas R, Fayyad-Kazan H, El Zein N, et al. Human nat- ural Treg microRNA signature: role of microRNA-31 and microRNA-21 in FOXP3 expression [ J]. Eur J Immunol, 2009, 39(6) : 1 608-618.
  • 10van der Fits L, van Kester MS, Qin Y, et al. MicroRNA- 21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sezary syndrome [ J ]. J In- vest Dermatol, 2010, Epub ahead of print.

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中国动脉硬化杂志
2010年 第8期

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