CD＋4CD＋25调节T细胞的生物学功能及其在移植物抗宿主病中作用的研究进展

Research advances of CD4^＋ CD25^＋ Treg cell and it＇s function in GVHD

CD＋4CD＋25调节T（Treg）细胞具有免疫无能性和免疫抑制性两大功能特征,是抑制性T细胞的一种亚群.能抑制效应细胞CD＋4T细胞和CD＋8T细胞的活化与增殖,从而有效抑制免疫系统对外来器官产生的排异反应,减轻了造血干细胞移植（HSCT）术后移植物抗宿主病（GVHD）,而且不影响移植物抗白血病（GVL）效应,从而在移植免疫耐受中发挥重要的作用.

CD＋4 CD＋25 regulatory T cell （Treg） has immune incompetent and immune suppression functions, and is a kind of suppressor T-cell subsets. It can inhibit the activation and proliferation of CD＋4 T cells and CD＋8 T cells, so as to effectively suppress the immune system to foreign organ and reduce the graftversus-host disease （GVHD） after hematopoietic stem cell transplantation （HSCT）, without affecting the role of graft-versus-leukemia （GVL）, which plays an important role in the transplantation immune tolerance.