急性白血病并发颅内出血临床分析

Clinical analysis of intracranial hemorrhage with acute leukemia

目的分析急性白血病患者颅内出血的高危因素,以便尽快采取防治措施,降低死亡率。方法分析该院血液科1994年9月~2009年12月发生颅内出血的急性白血病患者41例（A组）的临床资料,并随机抽取同期住院的无颅内出血的急性白血病患者43例为对照组（B组）。结果入院时高白细胞血症患者及合并DIC患者更容易合并颅内出血,在疾病终末期合并感染、血小板减少也是颅内出血的主要原因。结论颅内出血与高白细胞、血小板严重减少、合并DIC及合并感染有关,应针对上述因素积极采取相应的措施,避免颅内出血的发生,提高完全缓解率及生存时间。

【Objective】 To analyze the high risk factors of intracranial hemorrhage（ICH） with acute leukemia（AL）,and take therapeutic measure as soon as possible to lower the mortality.【Methods】To analyze the clinical data of 41 AL patients with ICH（Group A） from Sep 1994 to Dec 2009,and choose hospitalized 43 patients with AL in the same period without ICH to as control group（Group B）.【Results】 Leukocytosis patients and the patients complicated with DIC resulted in ICH easily.At the terminal stage of disease con-current infection and thrombocytopenia are also the main cause.【Conclusion】 ICH are relevant to leukocyto-sis,severe thrombocytopenia,concurrent infection,concurrent DIC.To aim directly at the above-mentioned factors,adopting active measure to evade ICH,raising the rate of complete remission and live time.