非枕叶癫痫患者视觉诱发电位的表现

The determination of VEP in patients with non-occipital lobe epilepsy

目的：研究非枕叶癫痫患者视觉传导通路可能的损害及其机制.方法：应用诱发电位仪对非枕叶癫痫中的难治性癫痫患者（第一组）、非枕叶癫痫中的非难治性癫痫患者（第二组）及健康志愿者（第三组）共3组进行视觉诱发电位（VEP）检测,观察其N75波潜伏期（LN75）、P100波潜伏期（LP100）、N75波幅（AN75）、P100波幅（AP100）等指标.结果：第一、二组的LN75、 LP100均较第三组延长,差异有统计学意义（P〈0.05）,而第一、二组间的LN75和LP100比较差异均无显著意义（P〉0.05） 第一组的AP100较第三组升高,差异有统计学意义（P〈0.05）,而第一、二组间比较差异无显著意义（P〉0.05） 三组间比较AN75比较差异均无统计学意义（P〉0.05）.结论： 非枕叶癫痫患者存在视觉传导异常,表现为LN75、LP100延长,AP100的升高 而其中的难治性癫痫患者与非难治性癫痫患者的视觉传导异常程度比较差异无统计学意义.

Objective：To explore the impairement of visual passway in patients with non-occipital lobe epilepsy（NOLE） and the possible mechanism of damage. Methods： The patients with NOLE were selected in this study including 43 cases（Group 1） with drug-responsive epilepsy and 34 cases with drugresistant epilepsy （Group 2）. And other 34 normal people served as the controls（Group 3）. The evoked potential machine was used to check visual evoked potential （VEP） in the 3 groups. Indexes of visual evoked eotential（VEP） including latency and amplitude of N75 and P100 waves were determined. Results：The latencies of N75 and P100 in the first two groups were longer than that in the Group 3（P〈 0.05）, but there was no difference between Group 1 and 2 （P〉0. 05）. The amplitudes of P100 in the second group were higher than that in Group 3（P〈0.05）, but there was no difference between Group 1 and 2 （P〉0.05）. There was no difference in amplitude of N75 in all the three groups （P〉0.05）. Conclusion： There is visual pathway impairment in NOLE, which shows the latencies of N75 and P100 are longer and amplitude of P100 is higher, but there is no difference between palients with drug-responsive epilepsy and patients with drug-resistant epilepsy.