高能紫外光治疗白癜风的临床观察

Clinical study on 304 nm UVB(DuaLight^(TM)UV120-2)in the treatment of vitiligo

目的:评价304 nm高能紫外光靶向治疗白癜风的疗效及安全性。方法:采用美国DuaLight^(TM)UV120-2型高能紫外光治疗仪治疗白癜风患者87例。治疗前判定皮肤类型,测定最小红斑量。照射起始剂量为最小红斑量的2倍,逐渐增加照射剂量,每周照射2次,规律治疗3个月后判定疗效。结果:87例患者中,痊愈14例,显效15例,好转53例,无效5例。有效率33.3%。进展期疗效好于稳定期,各部位之间疗效差异无统计学意义。不良反应为红斑、轻度瘙痒等,均可自行消退。结论:304 nm高能紫外光治疗白癜风起效快,疗效肯定,能最大限度保护白斑周围正常皮肤。局部不良反应少,是一种简单、安全的治疗方法。

Objectives： To evaluate the therapeutic efficacy and safety of 304 nm UVB in the targeted treatment of vitiligo. Methods： Eighty-seven patients with vitiligo were treated by 304 nm UVB twice a week, with DualightTM UV 120-2 targeted phototherapy system （Theralight Inc. USA）. The skin type and the minimal erythema dose （MED） were measured before treatment. The initial dosage was 2 times of MED, and the dosage was gradually increased. The efficacy and safety were evaluated 3 months later. Results： Out of 87 cas- es, 14 cured, 15 significantly improved, 53 moderately improved, and 5 without improvement. The total response rate was 33.3%. The adverse reactions were slight erythema and pruritus which resolved spontaneously. The efficacy was related to the clinical stage of the lesions, not to the location of the lesions. Conclusion： 304 nm UVB therapy is an effective and safe method to treat vitiligo, which could be used to protect the normal skin around the lesions.