摘要
目的确定司来吉兰贴片的处方及研究方法。方法通过正交设计试验研究确定司来吉兰贴片各组分的含量。结果司来吉兰经皮给药系统的最佳处方组成为:主药量为3%,促渗剂选用氮酮,含量为3%,增塑剂含量为15%,压敏胶含量为60%。背衬材料为涂铝膜的聚酯膜。结论司来吉兰适合制成经皮给药系统。正交设计实验是研究司来吉兰贴片处方的有效方法。
Objective To determine the prescription of selegiline transdermal patches.Methods The selegiline transdermal patches were prepared and the ingredient amount of selegiline transdermal patches was determined according to the orthogonal design.Results The best prescription of selegiline transdermal patches：3%selegiline,3%Azone,15%RS100,60%PSA.Conclusion Selegiline is suitable for the transdermal therapeutic systems.Orthogonal design of prescription was suitable to study selegiline transdermal patches.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2010年第9期746-748,共3页
Journal of China Medical University
关键词
司来吉兰
贴片
正交设计
处方
selegiline
patches
orthogonal design
prescription
