冠心病患者血清可溶性OX40配体和CRP水平的临床意义

Clinical Significance of Serum Soluble OX40 Ligand and C Reactive Protein Levels in Patients with Coronary Heart Disease

目的探讨不同类型冠心病患者血清可溶性OX40配体(sOX40L)和C反应蛋白(Creactive protein,CRP)水平的临床意义。方法分别采用ELISA法和免疫透射比浊法检测458例疑似或诊断为冠心病患者血清sOX40L和CRP的浓度,采用冠脉造影术和ACC/AHA评分法判定冠状动脉病变程度。结果急性冠脉综合征(ACS)组患者血清sOX40L和CRP水平及冠脉评分均明显高于稳定型心绞痛(SAP)组和正常对照(CT)组(P<0.01);sOX40L与CRP及冠脉评分均呈正相关(P<0.01),CRP与冠脉评分亦呈正相关(P<0.01)。结论血清sOX40L和CRP水平与冠心病患者的病情严重程度及冠状动脉病变程度密切相关,sOX40L有望与CRP一样,作为炎症指标预测冠心病的发生和预后。

Objective To study the clinical significance of serum soluble OX40 ligand （sOX40L）and C reactive protein （CRP）levels in the patients with coronary heart disease （CAD）. Methods The serum sOX40L and CRP concentrations of 458 patients or suspected patients with CAD were determined by ELISA and immunoturbidimetric method respectively. The severity of coronary artery lesion was evaluated according to coronary angiography and ACC / AHA coronary scoring system. Results The serum sOX40L and CRP levels as well as coronary scoring were significantly higher in acute coronary syndrome （ACS）group than in stable angina（SAP）and normal control（CT）groups（P 0. 01）. The sOX40L level was positively related to the CRP level and coronary score（P 0. 01）, and the CRP level was also positively related to the coronary score（P 0. 01）. Conclusion The serum sOX40L and CRP levels were closely related to the severities of CAD and coronary artery lesion. Like CRP, sOX40L might also be used as an marker of inflammation for prediction of onset and prognosis of CAD.