牙种植钛基生物材料表面骨形态发生蛋白修饰的固定与评价方法

Methods of BMP immobilization and evaluation for Ti-based dental implant surface modification

Ti-based biomaterial has been widely used as dental and bone implant material although its bioacti-vity still needs improvement especially for dental implant.The bone morphogenetic proteins(BMPs) bound to Ti-based materials will attract the mesenchymal stem cells to differentiate into osteoblast cells,which benefits the response to the protein-material surface,and finally leads to new bone formation.Several methods including physically mixing,coating,plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials.The latest research papers are focused on the structure and function of BMPs,and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.

Ti-based biomaterial has been widely used as dental and bone implant material although its bioactivity still needs improvement especially for dental implant. The bone morphogenetic proteins （BMPs） bound to Tibased materials will attract the mesenehymal stem cells to differentiate into osteoblast ceils, which benefits the response to the protein-material surface, and finally leads to new bone formation. Several methods including physically mixing, coating, plasma immobilization and cross-linking were used to investigate how BMPs bind to Ti-based biomaterials. The latest research papers are focused on the structure and function of BMPs,and the methods to bind BMPs to Ti-based biomaterial and the evaluation methods after protein immobilization are reviewed in this paper.