一氧化氮和一氧化氮合酶基因多态性与糖尿病视网膜病变

NO and NOS on genetic polymorphisms of diabetic retinopathy

糖尿病视网膜病变(diabetic retinopathy,DR)是重要致盲性眼病之一,其发生和进展与血糖水平、疾病病程、环境及遗传等多种因素有关。一氧化氮(NO)作为一种重要的血管活性物质,与DR中毛细血管闭塞、微循环障碍、内皮细胞增殖相关。一氧化氮合成酶(NOS)是NO合成过程中的关键酶,我们就NO和NOS基因多态性与DR的关系进行综述。

Diabetic retinopathy （DR）is one of important eye diseases that may cause blindness. Its occurrence and development is related to blood glucose level, duration of diabetes,environment and genetics. Nitric oxide （NO） is an important vasoactive substance which correlate with capillary occlusion, microcirculation disturbance, endothelial cell proliferation in DR. Nitric oxide synthase （NOS） is now accepted as a key enzyme of NO synthesis. The functions of NO and NOS on genetic polymorphism to DR are summarized in this review.