摘要
A method of sequence-based typing（SBT） has been adopted to assort types of exons 2 and 3,which have the most polymorphism,of HLA-B locus of the Tujia nation group in Hubei province.The correlation among the HLA-B alleles,human papillomavirus（HPV） infection and cervical cancer risk has also been investigated.Under the condition of resident location and age,race unified,100 specimens of cancer patients were sampled as a case group,of which 86 were HPV positive and were screened for HLA-B alleles;while 187 specimens were taken from healthy people,of which 92 were HPV negative as a control group.The result shows that by comparing the above mentioned 86 HPV positive cervical cancer group and 92 HPV negative normal group,it was concluded that HLA-B＊6701 was only found in the cervical cancer group（p〈0.034）,which shows that HLA-B＊6701 can be used as an important candidate biological marking gene for generation of cervical cancer in Wufeng county of Hubei province.
A method of sequence-based typing（SBT） has been adopted to assort types of exons 2 and 3,which have the most polymorphism,of HLA-B locus of the Tujia nation group in Hubei province.The correlation among the HLA-B alleles,human papillomavirus（HPV） infection and cervical cancer risk has also been investigated.Under the condition of resident location and age,race unified,100 specimens of cancer patients were sampled as a case group,of which 86 were HPV positive and were screened for HLA-B alleles;while 187 specimens were taken from healthy people,of which 92 were HPV negative as a control group.The result shows that by comparing the above mentioned 86 HPV positive cervical cancer group and 92 HPV negative normal group,it was concluded that HLA-B＊6701 was only found in the cervical cancer group（p〈0.034）,which shows that HLA-B＊6701 can be used as an important candidate biological marking gene for generation of cervical cancer in Wufeng county of Hubei province.
基金
Supported by the National Natural Science Foundation of China (300250008)
