急进高原人群红细胞谷胱甘肽、谷胱甘肽过氧化物酶和超氧歧化酶的变化

The Variances of the Levels for Glutathione,Glutathione Peroxidase and Superoxid Dismutase in Red Blood Cells Among Population After Rapidly Entering Plateau

为探讨急进高原环境人群，早期适应过程中红细胞抗氧化指标—谷胱甘肽（ＧＳＨ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）和超氧歧化酶（ＳＯＤ）的变化及其生理意义。以急进高原的健康人群为研究对象，年龄１８～２１岁。分为对照组和高原低氧组进行研究。结果表明高原低氧组红细胞ＧＳＨ含量和ＧＳＨ－Ｐｘ活力显著低于对照组（Ｐ＜０．０５）。高原低氧组红细胞ＳＯＤ含量显著高于对照组（Ｐ＜０．０５）。说明人体急进高原后血红细胞中抗氧化系统发生一系列适应性反应，但在低氧适应过程中的生理作用仍需进一步探讨。

To study the variances and physiological significances of levels of glutathione(GSH),glutathione peroxidase(GSHPx)and Surperoxide dismutase(SOD)in human red blood cells(RBC) as RBC antioxidation indicaters in persons during the early stage for adaptation after rapidly entering plateau,a research on the healthy population rapidly entering plateau aged 18￣21 years old,devided into control group(70 persons)and plateau hypoxia group,were carried outThe results showed that the levels of GSH and the activities of GSHPx in plateau hypoxia group were both significantly lower than those of the control group(P<005)The levels of SOD in plateau hypoxia group were higher than those in the control group significantly(P<005)It indicated that the antioxidation systems in RBC for human after rapilly entering plateau presented a serial adaptative changes,but their phsiological role in this adaptations reguired to be further studied