骨髓间充质干细胞分化为心肌细胞的研究进展

Advance in research of bone marrow mesenchymal stem cells differentiating into cardiomyocytes

骨髓中至少存在两种干细胞:造血干细胞(Hemopoietic stem cells,HSCs)和间充质干细胞(Mesenchymal stemcells,MSCs)。以前认为MSCs的重要作用是支持造血,近来的研究发现MSCs具有自我更新和多向分化的潜能。缺血性心脏病因其功能性心肌细胞减少而发生心室重构,最终导致心力衰竭,严重威胁着人类的身体健康。MSCs在体外或体内可诱导分化为心肌样细胞,并应用于缺血性心脏病的治疗,通过减少梗死面积,改善心肌功能,为心脏病的治疗提供了新途径。骨髓间充质干细胞的来源广泛,取材方便,较易培养已成为研究的热点。

Mesenchymal stem cells （MSC）previously recognized as critical to the support of hematopoiesis. Recently More researches foumd that MSCs can self-renew and have the potential of multilineage differentiation.They can differentiate into osteoblasts, chondrocytes, adipocytes, Myoblasts, neuron, hepatocyte, myoeyte, lschemic heart disease is seriously threat to human health. Resent findings show that intramyocardial implantation of MSCs can improve cardiac function, MSCs implantation provide a new way to repair the injured tissues. The study on progress of the differentiation of MSCs into cardiomyocyte, etc. were reviewed.