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MFG—E8的生物学功能及应用 被引量：5

Biological Function and Application of MFG-E8
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摘要 乳脂球表皮生长因子8（milk fat globuleEGF factorⅧ，MFG—E8）是一种乳汁脂肪小球表面的亲脂性糖蛋白，广泛参与多种细胞问的相互作用，如介导精子与卵子外膜问的结合、维持附睾上皮细胞与精子细胞膜的黏附、参与肠上皮细胞的维持与修复、促进乳腺支化形成和成人组织新生血管形成、增强树突状细胞外泌体功能以及参与吞噬清除凋亡细胞的过程。此外，MFG—E8也显示良好的应用前景，有可能作为潜在的治疗和检测手段。 The multi-domain protein milk fat globule EGF factor VIII （MFG-E8） is known to participate in a variety of cellular interactions, including adhesion between sperm and egg coat, repair of intestinal mucosa, mammary gland branching morphogenesis, angiogenesis, phagocytosis of apoptotic cells and so on. This unusual protein may offer much potential for research and therapeutics.
作者 李金丽(综述) 崔天盆(审阅)
机构地区 武汉市中西医结合医院临床免疫学实验室
出处 《医学分子生物学杂志》 CAS CSCD 2010年第5期467-470,共4页 Journal of Medical Molecular Biology
关键词 乳脂球表皮生长因子8 细胞问相互作用 凋亡清除 MFG-E8 intercellular interactions apoptosis clearance
分类号 R392.11 [医药卫生—免疫学]
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参考文献30

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同被引文献34

  • 1钱海英.肿瘤标志物CA153、CA125、CEA联合检测在乳腺癌中的临床应用[J].医学检验与临床,2008,20(2):33-33. 被引量：9
  • 2陈曼丹,陈林兴.抗核抗体谱在自身免疫性疾病的检测及应用[J].实用医技杂志,2005,12(02A):302-304. 被引量：26
  • 3邢艳（综述）,唐中（综述,袁国华（审校）.抗核抗体的研究进展[J].国外医学（内科学分册）,2006,33(5):218-221. 被引量：17
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  • 6Stubbs JD,Lekutis C,Singer KL,el al. cDNA cloningof a mouse mammary epithelial cell surface protein re-veals the existence of epidermal growth factor-like do-mains linked to factor flj-like sequences[J]. Proc NatlAcad Sci USA,1990’87(21) : 8 417-8 421.
  • 7Deroide N,Li X,Lerouet D,el al. MFGE8 inhibits in-flammasome-induced IL-lp production and limits pos-tischemic cerebral injury[J]. J Clin Invest,2013,123(3): 1 176-1 181.
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医学分子生物学杂志
2010年 第5期

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