遗传因素在不明原因复发性流产中的作用

Hereditary Factor of Unexplained Recurrent Spontaneous Abortion

不明原因复发性流产(URSA)是多基因控制的复杂疾病,发生率约占复发性流产的50%。近年大量研究表明,URSA与基因多态性有密切的关系,免疫系统中人类白细胞抗原(HLA)、细胞因子基因多态性;遗传性易栓症相关基因纤溶酶原激活抑制物(PAI-1)、V因子、人类亚甲基四氢叶酸还原酶(MTHFR)及载脂蛋白等基因多态性均与URSA有关;另外,孕激素受体(PR)、胰岛素生长因子等基因多态性也与URSA有关。因此,从基因水平上阐明URSA的发病机制,给临床预防、治疗和预后提供指导,是目前URSA病因学研究的热点。

Unexplained recurrent spontaneous abortion（URSA）is a complex disease controlled by various genes.The occurrence of URSA is estimted as 50% of recurrent spontaneous abortion（RSA）.Recently,many studys indicate that there are compact association between URSA and gene polymorphisms.There are association between URSA and human leucocyte antigen （HLA） of immune system and cell factor gene polymorphisms,inherited thrombophilia correlated gene plasminogen activator inhibitor （PAI-1）,V factor,methylene tetrahydrofolate reductase（MTHFR）and apolipoprotein,progesterone recepto（rPR）and insulin-like growth factor gene polymorphisms.It’s pathogenesis is illuminated at the gene level,which will guide clinical prevention,therapy and prognosis.Today,the survey on URSA is becoming hot spot increasingly.This text will overview these correlated surveys in recent years.